ERK1/2 MAP kinases: structure, function, and regulation
ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this primary structure requirement, many …
Extracellular signal-regulated kinases - Wikipedia
In molecular biology, extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions …
经典且复杂的细胞信号通路：RAS/RAF/MEK/ERK - 知乎
ERK进入细胞核后直接磷酸化转录因子Elk-1的多个位点，如Ser383 和 Ser389 等。 磷酸化后的Elk-1构象发生改变，与血清反应因子（SRF）的相互作用，形成高活性的转录因子复合物。
ERK家族成员 - 百度百科
ERK是extracellular regulated protein kinases的英文缩写，指细胞外调节蛋白激酶，包括ERK1和ERK2，是将信号从表面受体传导至细胞核的关键。许多其他信号通路明显活化时，可活化蛋 …
How ERK1/2 Activation Controls Cell Proliferation and Cell Death …
Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-activated protein kinase super family that can mediate cell proliferation and apoptosis. The …
快速了解ERK/MAPK信号通路？ - 知乎专栏
erk是一种丝氨酸/苏氨酸蛋白激酶，是一种传递有丝分裂原信号的信号转导蛋白。erk通常位于细胞质中；在被激活后，erk进入细胞核，调节转录因子活性和基因表达。erk家族已被证实包 …
ERK signalling: a master regulator of cell behaviour, life and fate
2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK …
ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?
In this review we compiled data on ERK1 vs. ERK2 gene structures, protein sequences, expression levels, structural and molecular mechanisms of activation and substrate recognition.
ERK1/2 MAP kinases: Structure, function, and regulation
2012年8月1日 · ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this …
The ERK 1 and 2 Pathway in the Nervous System: From Basic …
The extracellular signal-regulated kinases 1 and 2 (ERK) cascade, member of the mitogen-activated protein kinases superfamily of signalling pathways, is one of the best characterized …