2024年12月25日 · FBP2 (Fructose-Bisphosphatase 2) is a Protein Coding gene. Diseases associated with FBP2 include Leukodystrophy, Childhood-Onset, Remitting and Fructose-1,6-Bisphosphatase Deficiency. Among its related pathways …

Fructose-bisphosphatase 2 is an enzyme that in humans is encoded by the FBP2 gene. [5] This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 2,6-bisphosphate to fructose 6-phosphate and inorganic …

FBP1在肿瘤发生阶段就具有重要作用，其机制是与多梳蛋白EZH2形成复合物，抑制具有促癌作用的EZH2的转录调控活性，因此肿瘤组织中FBP1的普遍下调加速了肝癌和肾癌的发生 【15】；FBP1还能够结合并促进NOTCH1的泛素化和蛋白酶体降解，抑制乳腺肿瘤发生 【16】。 此外，在肾细胞中发现部分FBP1能够入核，直接与低氧诱导因子（hypoxia inducible factor/HIF）结合并抑制其转录活性，从而阻滞糖酵解和细胞增殖 【17】；而在肝细胞中，FBP1的缺失会引 …

2020年3月16日 · While hepatic fructose-1,6-bisphosphatase is well known as a key enzyme for gluconeogenesis, the role of muscle fructose-1,6-bisphosphatase 2 (Fbp2) in glucose disposal and thermogenesis is...

Here, we show that expression of the gluconeogenic isozyme fructose-1,6-bisphosphatase 2 (FBP2) is silenced in a broad spectrum of sarcoma subtypes, revealing an apparent common metabolic feature shared by diverse STSs. Enforced FBP2 expression inhibits sarcoma cell and tumor growth through two distinct mechanisms.

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis. The Reverse Warburg Effect is Associated with Fbp2-Dependent Hif1alpha Regulation in Cancer Cells Stimulated by Fibroblasts. MiR-591 could suppress FBP2 expression.

This gene encodes a gluconeogenesis regulatory Enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]

2018年9月11日 · 人类FBPase的基因分为fbp1和fbp2两种, 分别表达两种亚型的同工酶, 即肝型FBPase (FBP1)和肌型FBPase (FBP2), 它们在蛋白质结构上的同源性大约为77% 。FBP1主要分布在肝脏和肾脏, 肝脏是糖异生的主要器官, 参与机体血糖水平的调节; 而肾脏在长时间饥饿或糖尿病 …

2025年1月4日 · FBP2 does negatively regulate cell growth, and reduced expression of FBP2 may contribute to carcinogenesis for gastric cancer. Title: Decreased fructose-1,6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells.

2025年2月8日 · Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the Induction and Maintenance of Long-Term Potentiation. Expression of Fbp2, a Newly Discovered Constituent of Memory Formation Mechanisms, Is Regulated by Astrocyte-Neuron Crosstalk.