INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene. [5] FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative …

酸性fgf（afgf）和碱性fgf（bfgf）是fgf的原型成员，因其等电点不同而得名。它们在氨基酸序列上有55%的同源性，大小相似。基于系统发育分析，fgfs可分为七个亚家族。也有研究提出存在8个fgf家族，fgf3形成一个单独的“家族”，只有一个成员。

2024年12月25日 · FGF3 (Fibroblast Growth Factor 3) is a Protein Coding gene. Diseases associated with FGF3 include Deafness, Congenital, With Inner Ear Agenesis, Microtia, And Microdontia and Deafness With Labyrinthine Aplasia, Microtia, And Microdontia. Among its related pathways are Downstream signaling of activated FGFR2 and Insulin receptor signalling cascade.

This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression.

该基因是通过其与小鼠 fgf3/int-2 的相似性来鉴定的，fgf3/int-2 是一种在小鼠病毒诱导的乳腺肿瘤中激活的原癌基因。 已在人类肿瘤中发现该基因的频繁扩增，这可能对肿瘤转化和肿瘤进展很重要。

2025年1月4日 · Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia. Syndromic congenital sensorineural deafness, microtia and microdontia resulting from a novel homoallelic mutation in fibroblast growth factor 3 (FGF3). Primer on FGF3.

2020年9月2日 · Fibroblast growth factors (FGFs) are broad-spectrum mitogens and regulate a wide range of cellular functions, including migration, proliferation, differentiation, and survival....

The FGF3 gene provides instructions for making a protein called fibroblast growth factor 3 (FGF3). This protein is part of a family of proteins called fibroblast growth factors that are involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and development ...

2025年2月8日 · Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia. Tekin M, et al. Am J Hum Genet, 2007 Feb. PMID 17236138, Free PMC Article. Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia.

Fgf3 and Fgf10 (602115) signals localized to the leading zone are required for rosette formation, atoh1a expression, and primordium migration. Nechiporuk and Raible (2008) proposed that the fibroblast growth factor source controls primordium organization, which, in turn, regulates the periodicity of neuromast deposition.