Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene. [5][6] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family.

2024年12月25日 · FGF4 (Fibroblast Growth Factor 4) is a Protein Coding gene. Diseases associated with FGF4 include Embryonal Carcinoma and Germ Cell Cancer. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in …

重组FGF4（rFGF4）蛋白的长期治疗可改善 胰岛素抵抗 并抑制脂肪巨噬细胞浸润和炎症。 与FGF1（泛FGFR配体）不同，FGF4具有更受限制的FGFR1c结合特异性，FGF4有效的抗高血糖和抗炎特性证明了其在治疗2型糖尿病（T2D）和相关代谢紊乱方面的巨大潜力。 rFGF4蛋白也可有效地使高脂肪饮食诱导的妊娠糖尿病 (GDM)小鼠的不良代谢表型正常化，同时在治疗GDM模型中胚胎的神经管缺陷方面非常有效。 从机制上讲，rFGF4治疗可抑制两种GDM模型的促炎信号 …

FGF4亚科： 由FGF4，5，6组成。 本亚科的所有成员是都有可裂解的N端信号肽的分泌蛋白，他们可作为细胞外蛋白质通过结合和激活 FGF受体 来调节生物学效应。 这些FGF激活FGF受体1-3和FGF受体4的c部剪接变异体。 FGF7亚科： FGF7家族由FGF3，7，10，22组成。 FGF3，7，10，22优先激活FGF受体2和FGF3和FGF10的b期剪接变异体，也激活FGF受体1的b期剪接变异体。 FGF8亚科： 该FGF8亚科由FGF8，17，18组成。 这个亚科的成员含有1个N端 …

Whereas FGF2 has primarily been studied as preparations of recombinant protein, FGF4 has been administered by means of gene therapy. Alferminogene tadenovec (Ad5FGF4) is FGF4 encoded within replication-deficient human adenovirus serotype 5.

Our study identifies FGF4 as a stress-responsive regulator of liver pathophysiology that acts through an FGFR4-AMPK-Caspase 6 signal pathway, shedding light on strategies for treating NAFLD and associated liver pathologies.

Here, we report that the differentiation of robust proportions of epiblast-like and primitive endoderm-like cells in mouse embryonic stem cell cultures emerges at the population level through cell-cell communication via a short-range fibroblast growth factor 4 (FGF4) signal.

2024年9月18日 · Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of …

2025年1月4日 · Title: The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.

FGF-4 Protein, Human是一种成纤维细胞生长因子 (FGF)，能够高效地转化 3T3 细胞，刺激内皮细胞增殖，迁移和蛋白酶的产生，具有心血管生成的活性。 FGF-4 蛋白协调胚胎发育、细胞增殖和分化，对于正常肢体和心脏瓣膜发育至关重要。 FGF-4可能通过诱导关键基因表达来促进胚胎磨牙牙芽发育。 Animal-Free FGF-4 Protein, Human (His) 是重组的 无动物源 FGF-4 蛋白，由 E. coli 表达，带有 C-His 标签。 FGF-4 蛋白协调胚胎发育、细胞增殖和分化，对于正常肢体和心脏瓣 …