The FKBP s, or FK506 binding proteins, constitute a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function, though not in amino acid sequence. [1] .

FKBP（FK506 结合蛋白）属于一类独特的免疫亲和素，可与免疫抑制剂（如 FK506 和雷帕霉素）相互作用。 FKBP 利用其肽基脯氨酰异构酶 (PPIase) 活性在蛋白质折叠过程中催化蛋白质中脯氨酰键的顺反转换。 FKBP 还可充当一组独特的分子伴侣。 FKBP 参与多种生化过程，包括蛋白质折叠、受体信号传导、蛋白质运输和转录。 FKBP 家族蛋白与其配体复合时，在 T 细胞活化中发挥重要的功能作用。 FKBP 通过与类固醇激素受体、激酶或其他细胞因子相互作用，在各种生理 …

FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs FK506 and rapamycin. FKBP12 functions as a cis/trans peptidyl prolyl isomerase (PPIase) that catalyzes interconversion between prolyl cis/trans conformations.

FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs FK506 and rapamycin. FKBP12 functions as a cis/trans peptidyl prolyl isomerase (PPIase) that catalyzes interconversion between prolyl cis/trans conformations.

2018年1月1日 · FKBP (FK506 Binding Protein), Table 1 FKBP classification with synonyms of gene and protein. In the 1970s, after a decade from the purification of cyclosporine, a selective immunosuppressant agent and potent tool in transplantation medicine, a novel molecule was purified from bacteria Streptomyces tsukubaensis.

2021年11月18日 · In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce.

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its members have fundamental roles in the regulation of signalling pathways involved in inflammation, adaptive immune responses, cancer and developmental biology.

2011年8月1日 · FKBPs participate in cancer cellular processes. FKBPs are implicated in cell growth and survival and apoptotic signaling pathways. FKBP51 provide a relevant tissue marker of chemo-sensitivities and radio-sensitivities. FKBP52 autoantibodies are promising diagnostic cancer biomarkers.

这种编码的蛋白质是一种顺反式脯氨酰异构酶，可与免疫抑制剂 FK506 和雷帕霉素结合。 它被认为介导钙调神经磷酸酶抑制。 它还与成熟的异源寡聚孕酮受体复合物以及 90 kDa 热休克蛋白和 P23 蛋白在功能上相互作用。 已发现该基因具有多个聚腺苷酸化位点。 可变剪接导致多个转录变体。 [RefSeq 提供，2009 年 3 月]

该蛋白质是一种顺反式脯氨酰异构酶，可结合免疫抑制剂 FK506 和雷帕霉素。 它与多种细胞内信号转导蛋白相互作用，包括 I 型 TGF-β 受体。 它还与多个细胞内钙释放通道相互作用，并协调四聚体骨骼肌兰尼碱受体的多蛋白复合物形成。 在小鼠中，该同源基因的缺失会导致先天性心脏病，称为左心室心肌致密化不全。 已经鉴定出编码相同蛋白质的多个可变剪接变体。 人类基因组包含五个与该基因相关的假基因，其中至少一个被转录。 [RefSeq 提供，2008 年 9 月]