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2024年12月25日 · FN1 (Fibronectin 1) is a Protein Coding gene. Diseases associated with FN1 include Spondylometaphyseal Dysplasia, Corner Fracture Type and Glomerulopathy With Fibronectin Deposits 2. Among its related pathways are Signaling downstream of RAS mutants and Integrin Pathway.

Fibronectin（纤连蛋白）是一种多功能的细胞外基质蛋白，也是一种高分子量的糖蛋白。 它可以结合细胞表面和细胞外基质中的多种组分，包括胶原蛋白、纤维蛋白、肝素、DNA 和肌动蛋白等。 Fibronectin可以分为血浆纤连蛋白（plasma FN）和细胞纤连蛋白（cFN）。 在血浆中以可溶性二聚体形式存在，而在细胞表面和细胞外基质中以二聚体或多聚体形式存在。 血浆纤连蛋白由肝细胞合成，并以一种非活性、紧密的构象存在于血流中，它是纤维蛋白凝块的一个主要组分。 细 …

该基因编码纤连蛋白，这是一种糖蛋白，在血浆中以可溶性二聚体形式存在，在细胞表面和细胞外基质中以二聚体或多聚体形式存在。 编码的前原蛋白经过蛋白水解处理以生成成熟蛋白。 纤连蛋白参与细胞粘附和迁移过程，包括胚胎发生、伤口愈合、血液凝固、宿主防御和转移。 该基因具有三个可选择性剪接的区域，有可能产生 20 种不同的转录本变体，其中至少有一个编码一种可进行蛋白水解加工的亚型。 一些变体的全长性质尚未确定。 [RefSeq 提供，2016 年 1 月]

与Cxcl4 -/- CD11b+单核细胞相比，WT CD11b+单核细胞上的促纤维化标志物Fn1、Arg1和Spp1的水平明显更高。 为了进一步研究Cxcl4驱动的Spp1+巨噬细胞活化是否影响纤维化发生，Cxcl4 -/-和WT对照小鼠接受MI或假手术。

2025年2月20日 · FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ... cd00063

2020年6月19日 · Here we report that fibronectin 1 (FN-1) promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts. With isobaric tags for...

The FN1 gene provides instructions for making two types of the fibronectin-1 protein: soluble plasma fibronectin-1 and insoluble cellular fibronectin-1. Liver cells produce soluble plasma fibronectin-1 and release it into the bloodstream, where it is mainly involved in …

Fibronectin 1 (FN1) is a glycoprotein found throughout the extracellular matrix that has a role in the onset and progression of cancer. However, its immune relationship with gastric cancer is still unclear. FN1 was systematically reviewed by Gene ...

Fibronectin 1 (FN1), encoded by the FN1 gene, is an important extracellular matrix protein that is crucial for various biological processes and normal tissue functions. FN1's impact on bone metabolism and skeletal diseases has historically received less attention, but increasing evidence suggests that FN1 protein participates in the regulation ...