FTY720是近几年新开发的一种 免疫抑制剂，该药选择性减少外周循环 淋巴细胞数，显著延长实验动物移植器官的生存，同时并不损害对病毒的免疫应答及免疫记忆功能，毒副作用低，并且与 …

Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction. It has been …

fty720 减弱小胶质细胞增生，通过减少 lps 介导的 p38 mapk 信号通路激活来调节小胶质细胞炎症表型。因此，fty720 具有直接的神经保护和抗炎特性，可促进整体神经保护。

The chemical modification of ISP-I yielded a new compound, FTY720, which has more potent immunosuppressive activity and less toxicity than ISP-I does. FTY720 has been shown to be …

fty720 进入体内后，迅速磷酸化成 fty720-p，fty720-p 能够诱导淋巴细胞表面的s1pr1持续内化并降解掉。因此，fty720 是一种s1pr1的激动剂，拮抗s1p与受体结合的生物学作用，导致 t、b 淋 …

2010年10月29日 · Oral fingolimod (FTY720/Gilenya; Novartis) is a first-in-class sphingosine 1-phosphate (S1P) receptor modulator that, in relapsing–remitting MS, has demonstrated...

Fingolimod hydrochloride (Fingolimod HCl, FTY720, FTY-720)，又称盐酸芬戈莫德，是有效的1-磷酸鞘氨醇(S1P)的拮抗剂，IC 50 为0.33 nM，也是S1P受体的激动剂，在复发型多发性硬化症 …

Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC 50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant.

Fingolimod hydrochloride (FTY720) is a first-in-class of sphingosine-1-phosphate (S1P) receptor modulator approved to treat multiple sclerosis by its phosphorylated form (FTY720-P). …

Fingolimod (FTY720) is a specific agonist that targets the remaining barrier-protective S1P receptors, without targeting S1PR2. In the present study, we explored whether FTY720 …