2024年12月25日 · FAT4 (FAT Atypical Cadherin 4) is a Protein Coding gene. Diseases associated with FAT4 include Van Maldergem Syndrome 2 and Hennekam Lymphangiectasia-Lymphedema Syndrome 2. Among its related pathways are Kidney development and Markers of kidney cell lineage. Gene Ontology (GO) annotations related to …

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene. [5] [6] FAT4 is associated with the Hippo signaling pathway. [7]

2023年9月1日 · Here, we report the mechanism by which FAT4 overexpression regulates anti-tumor immunity in cervical cancer by inhibiting PD-L1 N-glycosylation and cell membrane localization in a β-catenin-dependent manner. Methods: FAT4 expression was first detected in cervical cancer tissues and cell lines.

对小鼠的研究表明，PCP 信号传导的缺失可能会导致囊性肾病，并且该基因的突变与 Van Maldergem 综合征 2 相关。 已注意到该基因的选择性剪接转录物变体。 [RefSeq 提供，2014 年 3 月] The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP).

The FAT4 gene provides instructions for making a protein that is found in most tissues. Learn about this gene and related health conditions.

大肠癌组织中fat4 的表达和yap 的表达呈负相关（r =-0.434，p＜0.01）。 FAT4 表达阳性者3 年生存率为84.62%，明显高于FAT4 表达阴性者的48.15%，差异有统计学意义（P＜0.01）；YAP 表达阳性者3 年生存率为44.89%，明

2023年2月16日 · Here, we determine the co-crystal structure of the human homologs Fat4 and Dachsous1 (Dchs1) to establish the molecular basis for Fat-Dachsous interactions. The binding domains of Fat4 and...

2019年3月4日 · FAT4 can regulate the activity of PI3K to promote autophagy and inhibit the EMT in part through the PI3K/AKT/mTOR and PI3K/AKT/GSK-3β signaling pathways.

Our study summarized and analyzed the antitumor effect of FAT4 in different tumors comprehensively, which aided in understanding the role of FAT4 in tumorigenesis from the perspective of clinical tumor samples. Pan-cancer analysis showed that FAT4 to be novel biomarkers for various cancers prognosis.

Katoh and Katoh (2006) determined that full-length FAT4 encodes a deduced 4,924-amino acid protein with 34 extracellular cadherin repeats. In silico analysis identified FAT4 mRNAs in fetal brain, infant brain, brain tumor, and colorectal cancer. Phylogenetic analysis revealed that FAT4 is divergent from FAT1 , FAT2 , and FAT3 .