2024年12月25日 · G6PC1 (Glucose-6-Phosphatase Catalytic Subunit 1) is a Protein Coding gene. Diseases associated with G6PC1 include Glycogen Storage Disease Ia and Hypoglycemia. Among its related pathways are Gene expression (Transcription) and Gluconeogenesis. An important paralog of this gene is G6PC2.

Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease). [6]

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3.

葡萄糖 6 磷酸酶 (G6Pase) 是内质网的多亚基整合膜蛋白，由催化亚基和 G6P、无机磷酸盐和葡萄糖的转运蛋白组成。 该基因 (G6PC) 是人类三种葡萄糖-6-磷酸酶催化亚基编码基因之一：G6PC、G6PC2 和 G6PC3。 6-磷酸葡萄糖酶催化 D-葡萄糖 6-磷酸水解为 D-葡萄糖和正磷酸盐，是葡萄糖体内平衡的关键酶，在糖异生和糖原分解中发挥作用。 该基因的突变会导致 I 型糖原贮积病 (GSD1) 。 这种疾病也称为 von Gierke 病，是一种代谢紊乱，其特征是严重的低血糖症与肝脏 …

2025年2月1日 · G6PC1 is an attractive target for type 1 and type 2 diabetes mellitus therapy by reducing blood glucose. Inhibiting G6PC1 curbs uncontrolled hepatic glucose production seen in these patients. By contrast, inhibiting G6PC2 reduces blood glucose levels, which is predicted to reduce the risk of several diseases including some forms of cancer.

2025年2月8日 · Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I …

2025年1月4日 · Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3.

Glucose-6-phosphatase catalytic subunit 1 (G6PC1) plays a critical role in hepatic glucose production during fasting by mediating the terminal step of the gluconeogenesis and glycogenolysis pathways. In concert with accessory transport proteins, this membrane-integrated enzyme catalyzes glucose prod …

葡萄糖-6-磷酸酶（G6Pase）是一种内质网的多亚基整合膜蛋白，由一个催化亚单位和G6P、无机磷酸盐和葡萄糖的转运子组成。 这个基因（G6PC）是人类三种葡萄糖-6-磷酸酶催化亚基编码基因之一：G6PC、G6PC2和G6PC3。 葡萄糖-6-磷酸酶催化D-葡萄糖-6-磷酸的水解为D-葡萄糖和正磷酸盐，是葡萄糖体内平衡的关键酶，在糖异生和糖原分解中发挥作用。 这个基因的突变导致I型糖原储存病（GSD1）。 这种疾病，也称为von Gierke病，是一种代谢紊乱，其特点是严重的低 …

2024年11月1日 · G6PC1 and G6PC2 are members of the glucose-6-phosphatase catalytic subunit (G6PC) gene family. Both G6PC1 and G6PC2 catalyze the hydrolysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate within the lumen of the endoplasmic reticulum (ER), though with different kinetics (Hutton and O’Brien 2009).