2024年12月25日 · G6PC2 (Glucose-6-Phosphatase Catalytic Subunit 2) is a Protein Coding gene. Diseases associated with G6PC2 include Glycogen Storage Disease Ia and Basophilic Adenocarcinoma. Among its related pathways are Gluconeogenesis and Glycolysis (REACTOME). Gene Ontology (GO) annotations related to this gene include glucose-6-phosphatase activity.

Glucose-6-phosphatase 2 is an enzyme that in humans is encoded by the G6PC2 gene. [5][6][7] This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family.

由该基因编码的家族成员存在于胰岛中，不表现出磷酸水解酶活性，但它是糖尿病中细胞介导的自身免疫的主要靶标。 已经描述了该基因的几种选择性剪接转录物变体，但尚未确定其生物学有效性。 [RefSeq 提供，2008 年 7 月] This gene encodes an Enzyme belonging to the glucose-6-phosphatase catalytic subunit family.

2025年2月8日 · Mutations in G6PC2 gene with increased risk for development of type 2 diabetes: Understanding via computational approach. G6PC indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis in vitro and in vivo.

Glucose-6-phosphatase catalytic subunit (G6PC)1 and G6PC2 are crucial for glucose metabolism, regulating processes like glycolysis, gluconeogenesis, and glycogenolysis. Despite their structural and functional similarities, G6PC1 and G6PC2 exhibit distinct tissue-specific expression patterns, G6P hydrolysis kinetics, and physiological functions.

2009年10月23日 · Glucose-6-phosphatase catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and inorganic phosphate. It is a multicomponent system located in the endoplasmic reticulum that comprises several integral membrane proteins, namely a catalytic subunit (G6PC) and transporters for G6P, inorganic phosphate, and glucose.

The G6PC1, G6PC2 and G6PC3 genes encode distinct glucose-6-phosphatase catalytic subunit (G6PC) isoforms. In mice, germline deletion of G6pc2 lowers fasting blood glucose (FBG) without affecting fasting plasma insulin (FPI) while, in isolated islets, glucose-6-phosphatase activity and glucose cyclin …

2025年2月8日 · Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose. Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic beta-cells.

2014年7月31日 · G6PC2属于G6PC家族蛋白，G6PC2过度表达能增加G6P的活性。 其可能抑制参与葡萄糖利用和葡萄糖刺激的胰岛素分泌的葡萄糖激酶活性。 此外，在几种糖尿病动物模型中胰岛G6PC2活性增加。 本文主要介绍G6PC2基因多态性与血糖调节及糖尿病的联系和转录调节以及编码蛋白的生物学功能。 【关键词】 葡萄糖-6-磷酸酶催化亚基-2;基因多态性;糖尿病. 【Summary】 Glucose-6-phosphatase (G6P) catalyzes the hydrolysis of glucose 6-phosphate (G6P) to …

g6pc2 基因座编码胰岛特异性葡萄糖 6-磷酸酶的催化 亚基，是 hba1c 和空腹血糖水平的既定风险基因座。糖酵解通量在调节胰高血糖素分泌中的关键作用是通过控制控制胰高血糖素分泌的葡萄糖抑制设定点的糖酵解酶葡萄糖激酶 (gck) 的活性和表达来确定的。