Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. [5] It is a type III intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS), including astrocytes [6] and ependymal cells during development. [7]

Glial fibrillary acidic protein (GFAP) is an intermediate filament structural protein involved in cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells. GFAP is neuroprotective, as knockout mice are hypersensitive to traumatic brain injury.

Glial Fibrillary Acidic Protein (GFAP) is a major protein found in the astrocytic cells of the brain, and it is considered a marker of astrogliosis, which is a characteristic feature of multiple sclerosis (MS) lesions.

2022年2月3日 · Glial fibrillary acidic protein (GFAP) levels reflect the clinical severity and extent of intracranial pathology after traumatic brain injury (TBI).

2024年12月25日 · GFAP (Glial Fibrillary Acidic Protein) is a Protein Coding gene. Diseases associated with GFAP include Alexander Disease and Canavan Disease . Among its related pathways are Signaling by ERBB4 and Selective autophagy .

2024年11月7日 · Glial fibrillary acidic protein (GFAP), a type III intermediate filament protein predominantly expressed in astrocytes, has emerged as a key biomarker for monitoring this response. During astrogliosis, GFAP is released into biofluids, making it a candidate for non-invasive diagnosis and tracking of neurodegenerative diseases.

Antibodies (Ab) targeting GFAP have been identified as the biomarker of a recently reported disorder: autoimmune GFAP astrocytopathy. 1 Detection of GFAP-Ab is recommended in the CSF by indirect immunofluorescence on rat brain tissues and cell-based assays (IFA and CBA) using GFAPα. 2 Autoimmune GFAP astrocytopathy is a rare entity that has ...