Glycerol-3-phosphate dehydrogenase 1 is an enzyme that is encoded by the GPD1 gene in humans. [5] This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family.

2024年12月25日 · GPD1 (Glycerol-3-Phosphate Dehydrogenase 1) is a Protein Coding gene. Diseases associated with GPD1 include Hypertriglyceridemia, Transient Infantile and Transient Infantile Hypertriglyceridemia And Hepatosteatosis. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism.

该基因编码 NAD 依赖性甘油 3-磷酸脱氢酶家族的成员。 编码的蛋白质通过催化磷酸二羟基丙酮 (DHAP) 和还原型尼古丁腺嘌呤二核苷酸 (NADH) 向甘油-3-磷酸 (G3P) 和 NAD+ 的可逆转化，在碳水化合物和脂质代谢中发挥关键作用。 编码的胞质蛋白和线粒体甘油 3-磷酸脱氢酶也形成甘油磷酸穿梭机，促进还原当量从胞质溶胶转移到线粒体。 该基因的突变是暂时性婴儿高甘油三酯血症的一个原因。 已经观察到该基因编码多种亚型的可变剪接转录物变体。 [RefSeq 提供，2012 年 …

Cytosolic Glycerol-3-phosphate dehydrogenase (GPD1), is an NAD+-dependent enzyme [8] that reduces dihydroxyacetone phosphate to glycerol-3-phosphate. Simultaneously, NADH is oxidized to NAD+ in the following reaction: GPD1 Reaction Mechanism. As a result, NAD+ is regenerated for further metabolic activity.

2021年7月19日 · 在呼吸链复合物I缺失（NDUFS2-KO）细胞中，过表达cGPD (GPD1/1L)可以增强Gro3P synthesis，激活GPD2介导的Gro3P shuttle, 把电子绕过复合物I传递给呼吸链，从而恢复代谢和细胞生长。

2024年5月1日 · GPD1, located in the cytosol, reduces the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to glycerol 3-phosphate (G3P) using two electrons from NADH, thus generating NAD +. On the...

GpD1 is a weight-loss-responsive gene in skeletal muscle. Its observed transcriptional modulation may decrease triglyceride synthesis, with weight loss. Identification and function of mutations in FAD-binding domain of mitochonrial glycerophosphate dehydrogenase in caucasians with type 2 diabetes mellitus.

证明gpd1是癌症干细胞有效靶点。据此，研究人员和著名的药物公司合作开发gpd1抑制剂，目前进展非常顺利。 因为gpd1是调控糖酵解及甘油代谢途径的关键酶，这说明休眠癌症干细胞在有效利用这个代谢途径。

2024年12月10日 · This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+.

2025年2月8日 · Enables glycerol-3-phosphate dehydrogenase [NAD (P)+] activity. Involved in NADH oxidation; intracellular accumulation of glycerol; and protein import into peroxisome matrix. Located in cytosol; nucleus; and peroxisome. Human ortholog (s) of this gene implicated in Brugada syndrome 2.