2024年9月8日 · Glucokinase (GCK) is a member of the hexokinase family, also known as hexokinase IV. It plays an essential role in glucose metabolism, crucial for sustaining blood glucose levels within normal ranges. It is a pivotal metabolic enzyme that catalyzes the first rate-limiting step of glycolysis in the pancreas and liver.

MODY 2 or GCK-MODY is a form of maturity-onset diabetes of the young. [1] It is due to any of several mutations in the GCK gene on human chromosome 7 for glucokinase. [2] Glucokinase serves as the glucose sensor for the pancreatic beta cell. Normal glucokinase triggers insulin secretion as the glucose exceeds about 90 mg/dl (5 mM).

2007年1月1日 · In this review we will focus on two subfamilies of the group, GCK-II and GCK-III, families that are closely related but, again, unique in their structural features and biological functions. Herein, we will present what we hope will be the current state of knowledge about these kinases, and discuss what remains to be done in order to better ...

2019年3月15日 · Glucokinase (GCK, hexokinase IV) is a monomeric enzyme that catalyzes the ATP-dependent conversion of glucose to glucose 6-phosphate, the first and rate-limiting step of glycolysis in the liver and pancreas [1, 2].

2012年9月10日 · GCK-I kinases are mitogen-activated protein kinase (MAPK) kinase kinase kinases that are termed MAP4Ks. GCK-I kinases can activate extracellular signal-regulated kinase, c-jun...

2024年9月8日 · Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver. Mutations in the GCK gene have been associated with various monogenic diabetes (MD) disorders, including permanent n …

Among the hexokinases, GCK displays unique enzyme kinetics in two respects. First, GCK has an affinity for glucose (S 0.5 ≅ 6 mM) more than 20 times lower than that of the next ranking hexokinase, hexokinase II. Second, the rate of the GCK reaction displays a sigmoid rather than hyperbolic dependence on glucose concentration . These two ...

In this review we will focus on two subfamilies of the group, GCK-II and GCK-III, families that are closely related but, again, unique in their structural features and biological functions. Herein, we will present what we hope will be the current state of knowledge about these kinases, and discuss what remains to be done in order to better ...

2024年9月8日 · 葡萄糖激酶 (gck) 是葡萄糖代谢中的关键酶，在胰腺 β 细胞的葡萄糖感应和胰岛素分泌以及肝脏中的糖原合成中发挥着核心作用。 GCK 基因突变与各种单基因糖尿病 (MD) 疾病相关，包括永久性新生儿糖尿病 (PNDM) 和青少年发病型糖尿病 (MODY)，这凸显了其在维持葡萄 ...

2012年9月10日 · GCK-I kinases regulate NF-κB activation, integrin activity, pathogen-associated molecular pattern signaling and inflammation. GCK-I kinases are mitogen-activated protein kinase (MAPK) kinase kinase kinases that are termed MAP4Ks.