2013年12月23日 · If the elimination rate slows half-life increases. By taking GFJ with bupe you are inhibiting the liver enzymes responsible for its metabolism, meaning less drug per unit time is eliminated. Regarding dosing. If you are on super doses of bupe, you may require more GFJ because they basically compete for the enzymes involved in their metabolism.

2006年7月26日 · i havent noticed any potentiation with xanax and grapefruit juice in the past, actually the only benzo i found to be potentiated by gfj in my body is valium. there's studies to back this too. 8 - 12 oz of 100% gfj 30-45 min before valium is supposed to add an hour or so to the tmax (time to max concentration in the blood) and be up to 3 times stronger.

2012年11月12日 · Yeah, I mean I know people who very elaborately and methodically dose potentiators at specific intervals, like for example, taking tagamet 1 hour before, drinking grapefruit juice 45 minutes before, taking diphenhydramine and/or hydroxyzine 30 minutes before, more tagamet and more GFJ 15 minutes before, benzodiazepines, and finally, their ...

2008年10月13日 · And that's exactly why GFJ IS a fairly good potentiatior: as it inhibits CYP3A4 (the unwanted one when it comes to metabolizing Codeine into Morphine) , hence, when Codeine is converted , it will undergo the hepatic metabolism by mostly CYP2D6, resulting in more moprhine, an optimized conversion and a longer half-life(as it'll take more time to ...

2017年3月26日 · For example it says that GFJ inhibits CYP3A4 and that temazepam is a substrate of CYP3A4. However from wikipedia only 10% of temazepam is processed this way and the rest is by phase II conjugation so it won't have that much of an effect.

2010年10月26日 · to get optimal results with GFJ, the user drinks multiple cups of GFJ. on the other hand, if you eat the actual grapefruit raw, has higher levels of bergamottin. the reason tagamet is effficient is because you can easily take 3-5 pills and get good inhibition, while with GFJ and grapefruits, you have to eat more to get the same effect.

2014年1月18日 · Personally when I used to try this the difference was negligible and didn't seem worth the cost of the Tagamet. GFJ however is delicious and is never a waste of your hard earned dollars. I've found dxm polistirex to potentiate almost everything my memory is hazy on whether it's worthwhile for benzos, but it certainly couldn't hurt.

2004年12月4日 · One study I looked at used 600mL to represent "a lot of grapefruit juice" and 200mL to represent a standard cup of GFJ; they found that 600mL was much much more effective at potentiation than 200mL. Ruby Red grapefruit juice is low in P450 competitive furanocoumarins and flavonoids compared to white grapefruit juice.

2010年6月11日 · GFJ potentiates almost all benzodiazepines. The only ones that aren't potentiated by GFJ are the 3-hydroxy family of benzos. These benzo's are temazepam, lorazepam, lormetazepam, oxazepam, and a couple of other more rare benzodiazepines that belong to the same family.

2011年1月30日 · But also interestingly enough it says hepatic inhibition only occurs at higher doses (of GFJ). So perhaps the reason Clonazepam, and I assume then other nitro-substituted benzos are only weakly (if at all) affected by GFJ is that you simply need to ingest a lot of it to get hepatic inhibition.