糖皮质激素诱导的亮氨酸拉链蛋白 (glucocorticoid-ind uced leucine zipper,GILZ)是近年来新发现的一个转录因子,属于转录因子TSC-22 (transforming growth factorβ-stimulated clone-22)家族。 …

Glucocorticoid-induced leucine zipper (GILZ) was originally discovered in studies aimed at characterizing genes targeted by dexamethasone. The first suggestion that GILZ plays an …

2013年5月7日 · 本文主要对 GILZ 的免疫抑制和抗炎功能、促进骨髓源性间充质干细胞(bone marrow-derived mesenchymal stem cells, BM-MSC) 的成骨细胞分化和抑制成脂肪细胞分化功 …

2021年12月30日 · The role of GILZ as an inhibitor of immune and inflammatory responses mediated by T lymphocytes has been confirmed by studies that have detected GILZ …

2019年8月6日 · Glucocorticoid-induced leucine zipper (GILZ) is a protein with multiple biological roles that is upregulated by glucocorticoids (GCs) in both immune and non-immune cells. …

2011年5月10日 · GILZ affects several major cell signaling pathways that regulate target genes involved in cell growth, cell differentiation, cell survival and inflammation. GILZ antagonizes …

Glucocorticoid-induced leucine zipper (GILZ) is a dexamethasone-inducible gene that mediates glucocorticoid (GC) actions in a variety of cell types, including many cells of immune system. …

We have identified a gene, glucocorticoid-induced leucine zipper (GILZ or tsc22d3), that is rapidly and invariably induced by GCs. Human GILZ is a 135-amino acid protein that mediates many …

2021年12月30日 · Here, we examine the mechanisms of GILZ in the context of GC. Specifically, we review its role in the proliferation and differentiation of cells and in apoptosis. We also …

Amongst a long list of genes activated by GCs is the Glucocorticoid Induced Leucine Zipper (GILZ). GC induced GILZ expression has been well established in lymphocytes and mediates …