2024年12月25日 · GLO1 (Glyoxalase I) is a Protein Coding gene. Diseases associated with GLO1 include Pulmonary Tuberculosis and Hyperglycemia. Among its related pathways are Regulation of pyruvate metabolism and Respiratory electron transport. Gene Ontology (GO) annotations related to this gene include lactoylglutathione lyase activity.

Glyoxalase I derives its name from its catalysis of the first step in the glyoxalase system, a critical two-step detoxification system for methylglyoxal. Methylglyoxal is produced naturally as a byproduct of normal biochemistry, but is highly toxic, due to its chemical reactions with proteins, nucleic acids, and other cellular components.

近期研究表明，人肿瘤细胞系和原发性肿瘤中发现了Glo 1 CNV，Glo 1拷贝数增加是癌症中Glo1表达增加的主要原因之一。 对520种人类肿瘤调查发现，大约有8%的肿瘤中Glo 1基因拷贝数增加，其中最高的是乳腺癌(19%)、小细胞肺癌(16%)和非小细胞肺癌(11%)( Tab 2 ) [ 8 ] 。

2012年11月18日 · Glyoxalase 1 (GLO1) is a ubiquitous cellular enzyme that participates in the detoxification of methylglyoxal (MG), a cytotoxic byproduct of glycolysis that induces protein modification (advanced glycation end-products, AGEs), oxidative stress, and apoptosis. The concentration of MG is elevated under high-glucose conditions, such as diabetes.

2020年11月1日 · GLO1 is a key rate-limiting enzyme in the glyoxalase system and it is linked to diabetes, cardiovascular disease, neurodegenerative disorders, and multidrug resistance in cancer chemotherapy. GLO1 regulators are developed to sustain healthy aging, to treat GLO1-related diseases and complications.

GLO1 lessened inhibitory phosphorylation of eNOS (Thr495) by reducing glycative stress. Study demonstrates that blunting glycative stress prevents the long-term impact of endothelial dysfunction on vascular aging. GLO1 is prevailingly expressed in cutaneous neoplasms of higher malignancy and contributes to the progression of squamous cell carcinoma

2021年5月8日 · Here, we found that disruption of GLO1, the gene encoding a major catabolic enzyme scavenging the carbonyl group, increases vulnerability to external carbonyl stress, leading to abnormal...

2024年10月21日 · Experimental validation showed that GLO1 expression affects the number of HCC cells in G2 and S phases and regulates HCC cell proliferation and migration. GLO1 represents a promising therapeutic target for HCC, providing valuable insights into its role in the viability and proliferation of HCC cells.

2012年11月19日 · Glyoxalase 1 (GLO1) is a ubiquitous cellular enzyme that participates in the detoxification of methylglyoxal (MG), a cytotoxic byproduct of glycolysis that induces protein modification (advanced glycation end-products, AGEs), oxidative stress, and apoptosis. The concentration of MG is elevated under …

在 rna 聚合酶 ii 的转录调节上游或调节内起作用。预测位于胞质溶胶中；核质；和质膜。在中枢神经系统和视网膜中表达。该基因的人类直系同源物与自闭症有关；糖尿病性视网膜病变;晚期肾脏疾病; 2型糖尿病；和血管疾病。与人 glo1（乙二醛酶 i）同源。