Glutathione: Uses, Interactions, Mechanism of Action - DrugBank …
Mechanism of action. Glutathione (GSH) participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase. It also plays a role in the hepatic biotransformation and detoxification process; it acts as a hydrophilic molecule that is added to other lipophilic toxins or wastes prior to entering biliary excretion.
Glutathione Homeostasis and Functions: Potential Targets for …
Glutathione (GSH) is a tripeptide, which has many biological roles including protection against reactive oxygen and nitrogen species. The primary goal of this paper is to characterize the principal mechanisms of the protective role of GSH against ...
Glutathione - PubMed
The functions of glutathione are manifold but notably include redox-homeostatic buffering. Glutathione status is modulated by oxidants as well as by nutritional and other factors, and can influence protein structure and activity through changes in thiol-disulfide balance.
(PDF) Glutathione: Biosynthesis and mechanism of action
2013年1月31日 · The Glutathione has a central role in biotransformation and elimination of xenobiotics and protects cells against oxidative stress. According to catalytic cycle we can identify the activity of...
Glutathione - an overview | ScienceDirect Topics
Glutathione (GSH) is one of the most important defenses against oxidative stress through the fine-tuned regulation of redox homeostasis. Glutathione is also involved in many metabolic processes and is important for the regulation of cell survival, proliferation, and death.
Glutathione: an overview of biosynthesis and modulation
1998年4月24日 · Glutathione (GSH; gamma-glutamylcysteinylglycine) is ubiquitous in mammalian and other living cells. It has several important functions, including protection against oxidative stress. It is synthesized from its constituent amino acids by the consecutive actions of gamma-glutamylcysteine synthetase a …
Glutathione - an overview | ScienceDirect Topics
Glutathione acts as an antioxidant by directly scavenging free radicals through the donation of a hydrogen atom. The synthesis of glutathione is homeostatically controlled, both inside the cell and outside (Meister 1974, 1983; Meister and Anderson 1983; Melikian et al. 1989). Glutathione is not taken up by pulmonary cells in its intact form.
An Update on Glutathione's Biosynthesis, Metabolism, Functions, …
Glutathione (GSH) has been the focus of increased scientific interest in the last decades. It plays a crucial role in all major physiological processes by supplying antioxidant defenses through participating in cellular redox reactions in the human body and other living organisms.
Glutathione-Related Enzymes and Proteins: A Review - MDPI
2023年2月2日 · Glutathione is determined as a marker of the redox state in many diseases, aging processes, and cell death resulting from its properties and reactivity. It also uses other enzymes and proteins, which enables it to engage and regulate various cell functions.
The antioxidant glutathione - ScienceDirect
2023年1月1日 · Reduced glutathione (GSH) is an essential non-enzymatic antioxidant in mammalian cells. GSH can act directly as an antioxidant to protect cells against free radicals and pro-oxidants, and as a cofactor for antioxidant and detoxification enzymes such as glutathione peroxidases, glutathione S-transferases, and glyoxalases.