Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene. [5] [6] This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family.

2024年12月25日 · GNRHR (Gonadotropin Releasing Hormone Receptor) is a Protein Coding gene. Diseases associated with GNRHR include Hypogonadotropic Hypogonadism 7 With Or Without Anosmia and Isolated Gonadotropin-Releasing Hormone Deficiency. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

Gonadotropin-releasing hormone (GnRH) that is produced in the hypothalamic neurosecretory cells is the main regulatory hormone of the HPG axis and acts in a pulsatile manner on the gonadotrope cells of the anterior pituitary gland by binding to GnRH receptors (GnRHRs) [1, 2, 3].

该受体是七次跨膜 G 蛋白偶联受体 (GPCR) 家族的成员。 它在垂体促性腺激素细胞以及淋巴细胞、乳腺、卵巢和前列腺的表面表达。 在结合促性腺激素释放激素后，该受体与激活磷脂酰肌醇-钙第二信使系统的 G 蛋白结合。 受体的激活最终导致促性腺激素黄体生成素 (LH) 和卵泡刺激素 (FSH) 的释放。 该基因的缺陷是低促性腺激素性性腺功能减退症 (HH) 的原因。 可变剪接导致编码不同异构体的多个转录变体。 该基因在 5' 区域有超过 18 个转录起始位点，在 3' 区域有多个 …

The gonadotropin-releasing hormone receptor (GnRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family.

c.364C>T in GNRHR is a complete loss-of-function mutation which caused idiopathic hypogonadotropic hypogonadism. GNRHR (and GNRH) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites. first description of a GNRHR gene mutation in three patients diagnosed with polycystic ovary syndrome.

结论 GnRH-R可能是乳腺癌潜在的治疗靶点，尤其是激素受体阴性的乳腺癌。 关键词： 促性腺激素释放激素受体（GnRH-R） 乳腺癌 组织芯片 预后. 1. Department of Breast Surgery, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China; 2....

2025年1月4日 · Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH).

促性腺激素释放激素（Gonadotropin-releasing hormone, GnRH）由下丘脑分泌，刺激或抑制垂体促性腺激素的分泌，有相当的活性潜能。 促性腺激素释放激素类似物（GnRHa）可以直接作用于肿瘤组织，引起细胞的凋亡。

Background: Gonadotropin-Releasing Hormone (GnRH) is a key element in sexual maturation and regulation of the reproductive cycle in the human organism. GnRH interacts with the pituitary cells through the activation of the Gonadotropin Releasing Hormone Receptors (GnRHR).