2020年5月6日 · Background: gp91 phox, the catalytic core of NADPH oxidase (NOX) and biomarker of NOX activation, has been recently recognized as a parameter of systemic oxidative stress in several studies. Subclinical hypothyroidism (SH) is characteristic of elevated level of serum thyroid stimulating hormone (TSH) and is frequently accompanied with ...

2022年12月11日 · 其中，关于NOX2（也称gp91 phox ）的研究最为深入。NOX2主要在吞噬细胞中表达，是吞噬细胞NADPH氧化酶的催化亚基，与p22 phox （p22）亚基形成异源二聚体，共同构成处于静息状态的NOX2-p22复合物 3 。

2021年6月1日 · Together with the NOX2/gp91 phox component present in the phagocyte NADPH oxidase assembly itself, the homologs are now referred to as the NOX family of NADPH oxidases. NOX are complex multidomain proteins with varying requirements for assembly with combinations of other proteins for activity.

1998年7月7日 · We found that gp91 phox expressed in the absence of p22 phox was targeted correctly to the plasma membrane and exhibited a reduced minus oxidized difference heme spectrum that was identical to that of neutrophil flavocytochrome b 558.

1998年7月7日 · The phagocyte NADPH oxidase flavocytochrome b558 is a membrane-bound heterodimer comprised of a glycosylated subunit, gp91(phox), and a nonglycosylated subunit, p22(phox). It contains two nonidentical heme groups that mediate the final steps of electron transfer to molecular oxygen (O2), resulting i …

2010年7月26日 · In the present study, we have shown that, in gp91 phox-/-mice, gp91 phox expressed in classically-activated microglial-like cells plays a key role in O 2-production after TBI, and that gp91 phox-derived O 2-is a key signal for contusion and cell death after TBI.

The phagocytic NADPH oxidase consists of a membrane-localized glycosylated, catalytic subunit, gp91 phox (which has also come to be known as Nox2, a terminology that will be used in this review), along with a second membrane-associated subunit, p22 phox, both depicted in Fig. 1.

Given the high prevalence of SH in the general population and undetermined correlation of oxidative stress with hyperthyrotropinemia and hyperlipidemia, we aimed to explore in this study the levels of gp91 phox as well as the effects of LDL …

2007年9月12日 · Gp91 phox is a transmembrane protein and the catalytic core of the NADPH oxidase complex of neutrophils. Lack of this protein causes chronic granulomatous disease (CGD), a rare genetic disorder characterized by severe and recurrent infections due to the incapacity of phagocytes to kill microorganisms.

2016年11月29日 · Gp91 phox, a plasma membrane subunit of NADPH oxidase (Nox), is constitutively expressed in BMMs and plays a major role in superoxide anion production. In this study, we found that mice deficient...