Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. [5] [6] [7] [8] There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart. [9]

2024年12月25日 · HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4) is a Protein Coding gene. Diseases associated with HCN4 include Sick Sinus Syndrome 2 and Brugada Syndrome 8. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses.

2025年3月1日 · Fig. 1: HCN4 antagonists or Hcn4 knock out prevent action potential rate increases by heat in SAN cells. Fig. 2: HCN4 current (I f) has a Q 10 of ~2.0 that is independent of cAMP signaling. In ...

2025年2月8日 · A novel mutation is found in HCN4 gene causing symptoms of sinus bradycardia in unrelated male Moroccan Jews. These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; HCN4 channels are expressed in different patterns in brain and heart; the N terminus is important for HCN4 channel activation

该基因的突变与病态窦房结综合征 2 有关，也称为房颤伴心动过缓或家族性窦性心动过缓。 已在 15 号染色体上鉴定出两个假基因。 [RefSeq 提供，2008 年 10 月] This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process.

2020年11月3日 · It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate regulation by the...

2013年8月2日 · Results demonstrated that, at cardiac crescent stages, HCN4 marks the first heart field, with HCN4CreERT2 allowing assessment of cell fates adopted by first heart field myocytes. Throughout embryonic development, HCN4 expression marked distinct CCS precursors at distinct stages, marking the entire CCS by late fetal stages.

The HCN4 gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated ion channel family, which are expressed at the cell membrane and contribute to the resting membrane potential. HCN4 is expressed in the heart and in several brain regions, including the thalamus (summary by Campostrini et al., 2018).

The HCN4 gene provides instructions for making a channel that transports positively charged atoms (ions) into heart muscle cells. This channel is located primarily in the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker.

hcn通道 共有4种：hcn1, hcn2, hcn3, 和hcn4。 自从HCN通道被发现后，它的超极化激活特性立即引起了科学研究者的重视。 HCN通道参与了许多神经活动,包括参与调节神经元活动的节律性和树突整合，调控细胞静息膜电位及突触传递等等。