5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene. [5][6] This gene is a member of the family of human serotonin receptors, which are G protein-coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine).

The acupuncture point "HT 4", 靈道, is represented by "Ling Dao" in pinyin and "Spirit Pathway" in english and may be found: 1.5 cun above the wrist crease on the radial side of the flexor carpi ulnaris tendon, on the HT 3 - HT 7 line.

Cardiac pain, sudden loss of voice. Functions: Calms the Shen, benefits the voice, benefits the muscles and sinews. Notes: Jing-River points are where the qi of the meridian begins to flow more heavily. They are known to treat cough and asthma due to pathogenic cold or heat. Needling: Perpendicular insertion .3 - .5 cun.

4-Hydroxytryptamine (4-HT, 4-HTA), also known as N,N-didesmethylpsilocin, is a naturally occurring tryptamine alkaloid. [1] [2] [3] [4] It is closely related chemically to the neurotransmitter serotonin, the psychedelic psilocin, and is the active form …

2019年4月25日 · The serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux.

In this work, we present a computational study of a three-dimensional quantitative structure-activity relationship (3D-QSAR) of a set of molecules with agonist activity on 5-HT 4 receptors. The calculations were carried out by using force- and Gaussian-field based QSAR models.

5‐HT 4 receptor agonists have been shown to be effective at treating various gastrointestinal tract disorders. However, a lack of selectivity against off‐targets has been a limiting factor for their clinical use.