Conditional VHL gene deletion activates a local NO-VEGF axis in a ...
Conditional VHL knockdown may enhance the NO-VEGF axis and protect glomerular endothelial cells from HV GN, thereby providing resistance to injury of tubular epithelial cells and …
Hantavirus Gn and Gc Envelope Glycoproteins: Key Structural Units for ...
In this review, current knowledge of the Gn and Gc structures and their functions in virus cell entry and exit is summarized. During virus cell entry, the role of Gn and Gc in receptor binding has …
The Hantavirus Surface Glycoprotein Lattice and Its Fusion …
2020年9月15日 · Here we report the X-ray structure of the metastable pre-fusion Gn H /Gc heterodimers of ANDV and Maporal virus (MAPV; an NWH closely related to ANDV) to 3.2- …
Self-association and subcellular localization of Puumala hantavirus ...
2019年1月24日 · Our findings suggest that PUUV Gc is the driving factor of the targeting of Gc and Gn to the Golgi region, while Gn possesses a significantly stronger self-association potential.
Conditional - Oxford Academic
2011年4月14日 · We have reported that tubular epithelial cell injury caused by renal ischemia−reperfusion is attenuated in conditional VHL knockout (VHL-KO) mice and also that …
The NO has a renoprotective role against HV GN in VHL-KO mice.
In control mice with HV GN, NO signals are completely attenuated throughout the kidney, especially in the glomeruli (control). However, in VHL-KO mice with HV GN, NO signals are …
Modification in the von Hippel-Lindau protein is involved in the ...
However, a role of the von Hippel-Lindau (VHL) protein in GN and mechanisms by which HV regulates the pathogenesis of GN remains unclear. Methods and results: …
The N-terminal Gn and C-terminal Gc have been suggested to be cleaved cotranslationally by cellular sig-nal peptidases (7). The interplay between Gn and Gc has a fundamental …
Modification in the von Hippel-Lindau Protein Is Involved in the ...
2007年2月1日 · Using a model of acute glomerulonephopathy induced by Habu snake venom (HV GN) (a glomerular endotheliumtargeted model), we have demonstrated that angiotensin II …
Analysis of glomerular VEGF mRNA and protein expression in …
2007年2月1日 · The present study documents temporarily increased glomerular VEGF gene and protein expression during the healing of HSV GN, suggesting a potential role of VEGF in the …