HAS2 is a member of the vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) …

2024年12月25日 · HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to …

HAS2 是新发现的编码假定乙酰透明质酸合酶的脊椎动物基因家族的成员，其氨基酸序列与非洲爪蟾的糖胺聚糖合成酶 (DG42) 以及人和鼠透明质酸合酶 1 具有显着同源性。[RefSeq 提 …

Our study provides evidence that HAS2 actively synthesizes HA in HSCs and that it promotes HSC activation and liver fibrosis through Notch1. Targeted HA inhibition may have potential to …

2023年8月23日 · Mice overexpressing Has2 from the naked mole-rat showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced …

HAS2 and HAS3 were the only hyaluronan synthases detected, the expression of which was almost similar in NPs and NM. HAS2 has been proposed to be a target for therapeutic …

In this work, we showed that the level of hyaluronic acid synthase 2 (HAS2) was positively correlated with the malignant phenotype of breast cancer cells. Notably, the increased …

2021年5月5日 · Hyaluronic acid synthase 2 (HAS2), giving rise to high-molecular-weight hyaluronan (HA) synthesis enriched in ECM [4, 5], is identified to play an important role in …

2016年12月6日 · HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to …

The human hyaluronan synthase 2 (HAS2) gene encodes for an enzyme making hyaluronan, altered concentrations of which are associated with many pathological situations including …