HATU (Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU is used along with Hünig's base (N,N-diisopropylethylamine), or triethylamine to form amide bonds.

O- (7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate | C10H15F6N6OP | CID 6409673 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

hatu是一种常用的多肽缩合试剂，应用在羧基与氨基合成肽键的反应之中，相对于其他类似缩合剂（如，hbtu）反应速度更快，不易消旋。利用hatu进行酰胺化反应，条件温和，产率高，很多大位阻的缩合剂也能反应，广泛应用于合成各种医药中间体。

N-Acylsulfonamide safety-catch linkers are versatile tools in solid-phase organic synthesis because of their stability. This stability necessitates linker activation prior to compound cleavage. Here, we demonstrate that the N-acylsulfonamide group can react with a pi-allyl palladium complex and that these.

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HATU - chemical structure, common uses, and safety.

HATU (H exafluorophosphate A zabenzotriazole T etramethyl U ronium) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU is used along with Hünig's base (N,N -diisopropylethylamine), or triethylamine to form amide bonds.

2022年2月10日 · HATU, 2-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, is a commonly used condensation reagent and is widely used in the synthesis of amide bonds. HATU promotes the formation of amide bonds by activating the carboxyl group.

2025年1月27日 · HATU, first prepared by Louis A. Carpino in 1993, is widely used in carboxylic acid amidation reactions. It acts as a facilitator of amide bond generation by activating the carboxyl group. Chemical Properties. White crystalline to off-white powder Uses

HATU 8 since its innovation, has been established as a peptide coupling reagent with enhanced reactivity, devoid of side product(s) formation and racemization in the formed products compared to other commonly used coupling reagents.