Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. [5] [6] HES1 is one of …

2024年12月25日 · HES1 (Hes Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with HES1 include Alagille Syndrome 1 and Strawberry Gallbladder. …

HES1/5 和 HEY1 ：编码基本环螺旋转录因子，是Notch信号通路下游效应分子中的代表成员。这些分子通过负性反馈机制抑制Notch信号通路的激活。

Hairy and enhancer of split-1 (HES1) is a basic helix-loop-helix transcription factor that is a key regulator of development and organogenesis. However, little is known about the role of HES1 …

2016年6月24日 · Hes1（hairy and enhancer of split 1）是一类DNA结合蛋白超家族的成员，它对于多种组织以及细胞的分化具有促进作用。 研究表明Hes1的表达受到多种天然免疫信号的影 …

Hes1 suppresses acute myeloid leukemia development through FLT3 repression. HES1 has a role in metastasis and predicts poor survival in patients with colorectal cancer; Hes1 oscillation …

Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, …

It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that …

split-1 的毛状增强子 (HES1) 是一种基本的螺旋-环-螺旋转录因子，是发育和器官发生的关键调节因子。 然而，人们对出生后 HES1 的作用知之甚少。 糖皮质激素是生命必不可少的主要应激激 …

2016年6月20日 · We found that the transcriptional repressor Hes1 suppressed production of CXCL1, a chemokine that is crucial for recruiting neutrophils. Hes1 negatively regulated …