Structure, substrate specificity, and catalytic mechanism of …
2021年1月12日 · The structural and biochemical data together reveal the molecular mechanism of the substrate specificity and catalytic reaction of D-2-HGDH and provide insights into the …
Grand Ducal Highness - Wikipedia
His or Her Grand Ducal Highness (abbreviation: HGDH) is a style of address used by the non-reigning members of some German ruling families headed by a Grand Duke. No currently …
Structure, substrate specificity, and catalytic mechanism of
2021年1月12日 · This work reports the crystal structures of human D-2-HGDH in apo form and in complexes with D-2-HG, D-malate, D-lactate, L-2-HG, and 2-oxoglutarate, respectively. D-2 …
2-Hydroxyglutarate (2-HG) is a low-abundance meta-bolite that exists in normal cells of many organisms but has unknown physiological function(s) for a long time1–5. It has two...
Progress in understanding 2-hydroxyglutaric acidurias - PMC
Accumulation of d -2-hydroxyglutarate (D-2-HG) and/or l -2-hydroxyglutarate (L-2-HG) in body fluids are the biochemical hallmarks of these disorders. The current review describes the …
研究揭示D-2-羟戊二酸脱氢酶对底物特异性识别和催化反应的分子 …
2021年1月15日 · 该研究揭示了人源FAD依赖的D-2-羟戊二酸脱氢酶（D-2-HGDH）对底物特异性识别和催化反应的分子机制，阐述了D-2-HGDH突变体在 遗传 学疾病D-2-羟戊二酸尿酸症发 …
D‐2‐hydroxyglutaric aciduria Type I: Functional analysis of
D‐2‐hydroxyglutaric aciduria Type I (D‐2‐HGA Type I), a neurometabolic disorder with a broad clinical spectrum, is caused by recessive variants in the D2HGDH gene encoding …
丁建平组揭示了D-2-羟戊二酸脱氢酶D-2-HGDH对底物特异性识别 …
2021年1月13日 · 该工作揭示了人源fad依赖的d-2-羟戊二酸脱氢酶（d-2-hgdh）对底物特异性识别和催化反应的分子机制，阐述了d-2-hgdh突变体在遗传学疾病d-2-羟戊二酸尿酸症发生中的作 …
Structural basis for stereo-specific catalysis in NAD ... - PubMed
NAD(+)-dependent (R)-2-hydroxyglutarate dehydrogenase (HGDH) catalyses the reduction of 2-oxoglutarate to (R)-2-hydroxyglutarate and belongs to the d-2-hydroxyacid NAD(+)-dependent …
Cell Discovery：D-2-羟戊二酸脱氢酶对底物特异性识别和催化反应 …
2021年1月15日 · 该研究揭示了人源FAD依赖的D-2-羟戊二酸脱氢酶（D-2-HGDH）对底物特异性识别和催化反应的分子机制，阐述了D-2-HGDH突变体在遗传学疾病D-2-羟戊二酸尿酸症发生 …