Human placental growth hormone (PGH), encoded by the growth hormone (GH) variant gene on chromosome 17, is expressed in the syncytiotrophoblast and extravillous cytotrophoblast layers of the human placenta. Its maternal serum levels increase throughout pregnancy, and gradually replaces the pulsatile secreted pituitary GH.

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1988年6月25日 · We have sought direct evidence for the in vivo expression of the human growth hormone-variant (hGH-V) gene by screening a placental cDNA library with a hGH-V-specific oligonucleotide. Nine independent hGH-V cDNA clones were isolated and analyzed, and three distinct species were detected.

Using young male Wistar rats fed either chow or a high-fat (HF) diet for 4 wk postweaning, we investigated the effect of 7 days treatment with either 22-kDa hGH-N, 20-kDa hGH-V (5 ug x g (-1) x day (-1) sc), or vehicle on body composition and endocrine and metabolic profiles.

Find out what is the full meaning of HGHV on Abbreviations.com! 'High Growth High Value' is one option -- get in to view more @ The Web's largest and most authoritative acronyms and abbreviations resource.

The human GH-variant (hGH-V) gene, a member of the GH-PRL gene family, is expressed by the placenta during the second and third trimesters of gestation. The secreted hGH-V protein differs from pituitary GH (hGH-N) by only 13 amino acids.

Several isoforms also derive from the GH gene expressed in the placenta (hGH-V)(Table 1). The most abundant mRNA from this gene in the placenta at terminus also codifies for a 22 kDa isoform.