2024年12月25日 · HHEX (Hematopoietically Expressed Homeobox) is a Protein Coding gene. Diseases associated with HHEX include Maturity-Onset Diabetes Of The Young and Heart Defects, Congenital, And Other Congenital Anomalies. Among its related pathways is …

2022年7月4日 · We discovered that HHEX, a transcription factor (TF) widely recognized as a key regulator of liver development, acts as a gatekeeper of pancreatic lineage specification.

The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional repressor that is of fundamental importance across species, as evident by its evolutionary conservation spanning fish, amphibians, birds, mice and humans.

2018年7月13日 · Here, using a combination of genetic and molecular approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and...

HHEX promotes hepatic specification by repressing EOMES expression. Data indicate the potential importance of CDKAL1 protein and homeobox protein HHEX in glucose homeostasis in this Alaska Native population with a low prevalence of type 2 diabetes (T2D).

2022年8月25日 · In this study, we observed that HHEX (Hematopoietically expressed homeobox) may enhance transcription activity of the YAP-TEAD complex. HHEX associates with and stabilizes the YAP-TEAD complex...

2010年8月26日 · Thus, Hhex is a critical regulator of hematopoietic development and is necessary for the maturation and proliferation of the earliest definitive hematopoietic progenitors. The hematopoietic stem cell (HSC), which maintains blood cell production throughout adult life, resides in the bone marrow.

2020年10月1日 · Mutant ASXL1 and HHEX promote myeloid leukemogenesis via upregulating the expression of MYB and ETV5. Inhibition of the HHEX-MYB/ETV5 axis would be a promising therapeutic approach for myeloid malignancies harboring ASXL1 mutations.

2023年2月17日 · The hematopoietically expressed homeobox (HHEX) gene plays an important role in embryonic development and organogenesis; however, the genetic variation and expression pattern of the porcine HHEX gene remains to be clarified.

2025年2月8日 · Hematopoietically-expressed homeobox protein HHEX regulates adipogenesis in preadipocytes. Hhex regulates murine lymphoid progenitor survival independently of Stat5 and Cdkn2a. The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development.