The Hox genes are a set of transcription factor genes that exhibit an unusual property: They provide a glimpse of one way in which gene expression is translated into the many different forms that...

Hox genes play many more roles in vertebrate development. They help specify the difference between an arm and a leg, as well as a pinky and a thumb. In the nervous system, their expression in segmented embryonic structures called rhombomeres directs the development of different brain regions.

Indeed, one of the most remarkable pieces of evidence for deep homologies among all the animals of the world is provided by the Hox genes. As mentioned in Chapter 11, not only are the Hox genes themselves homologous, but they are in …

A Hox gene is defined as an evolutionary homologue of transcription factor genes found in all vertebrates, with multiple complexes in mammals. These genes exhibit colinearity in their expression along the body axis, reflecting their order on the chromosome. AI generated definition based on: Brain Research Bulletin, 2001

Hox genes encode evolutionarily conserved transcription factors that are essential for the proper development of bilaterian organisms. Hox genes are unique because they are spatially and temporally regulated during development in a manner that is ...

2025年2月11日 · Hox genes, a subset of homeotic genes, are integral to the genetic framework determining an organism’s body plan during embryonic development. Highly conserved across species, these genes provide cells with positional information crucial …

2014年1月1日 · Human HOX disorders show variation in inheritance, pathogenesis and expressivity. We review phenotypes, inheritance and molecular genetics of human HOX disorders. Mouse models will aid clinicians in identifying additional human Hox disorders.

2024年11月20日 · We analyse HOX gene expression across cell types during development, finding that neural-crest derivatives unexpectedly retain the anatomical HOX code of their origin while also adopting the...

2023年1月1日 · Here, we provide an overview of Hox genes, highlighting their evolutionary history, their unique genomic organization and how this impacts the regulation of their expression, what is known about their protein structure, and their deployment in development and beyond.

In this commentary, we highlight recent reports that have provided novel insight into the origins of the mammalian Hox cluster, the role of Hox genes in the generation of a limbless body plan, and a novel putative mechanism in which Hox genes may encode specificity along the AP axis.