2024年12月25日 · Complete information for HOXD@ gene (Gene Cluster), Homeobox D Cluster, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

HOXD13 is the first of several HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd13 gene plays a role in axial skeleton development and forelimb morphogenesis. [8]

同源异型基因 （英语： homeotic genes）是生物体中一类专门调控生物形体的基因，一旦这些基因发生突变，就会使身体的一部分变形。 其作用机制，主要是调控其他有关于细胞分裂、纺锤体方向，以及硬毛、附肢等部位发育的基因。 colinearity共线性发育. 果蝇的Hox基因皆位在其 3号染色体 右臂上，可分为两个群集：双胸复合群（Bithorax complex，BX-C）和触足复合群（Antennapedia complex，ANT-C）果蝇分节情况为：头、T1~T3、A1~A8、性器。 双胸复合 …

2022年11月1日 · HOXD genes are characterized as oncogene or tumor suppressors to modulate the biological function of cancer cells. HOXD genes are able to be a crucial target for the diagnosis and therapy of tumors. The transcription factors (TFs) of the HOX family play significant roles during early embryonic development and cellular processes.

HOXD8 directly activates the transcription of HOXC9, a key effector of RA action in neuroblastoma cells. These findings highlight the distinct functions of HOXD genes in RA induction of neuroblastoma cell differentiation.

Hox基因（英语：Hox genes）全名 同源基因 （英语：homeotic genes）或同源异型基因。 是生物体中一类专门调控生物形体的基因，一旦这些基因发生突变，就会使身体的一部分变形。 其作用机制，主要是调控其他有关于细胞分裂、 纺锤体 方向，以及硬毛、 附肢 等部位发育的基因。 Hox基因属于 同源异型盒 （homeobox）家族的其中一员，在大多数Hox基因中，会含有一段约180个 核苷酸 的同源异型盒，可以转录出含有约60个 氨基酸 序列，称为 同源蛋白质 区 …

During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy involving two topologically associating domains (TADs) located on either side of the gene cluster. This work shows that the HOX13 proteins themselves help ...

2024年12月25日 · HOXD3 (Homeobox D3) is a Protein Coding gene. Diseases associated with HOXD3 include Leukemia, Acute Lymphoblastic and Synpolydactyly. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

2024年12月25日 · HOXD13 (Homeobox D13) is a Protein Coding gene. Diseases associated with HOXD13 include Synpolydactyly 1 and Syndactyly, Type V. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is HOXA13.

In this issue of Genes & Development, Beccari and colleagues (pp. 1172–1186) make a big step forward in understanding Hox gene regulation during limb development by showing the pivotal role of HOXA13 and HOXD13 proteins in the transition from a proximal to a distal type of Hoxd transcriptional regulation.