HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that …
This protein is a member of the large oligomerization domain (NOD)-like receptor-family of cytoplasmic immune receptors, which upon the detection of certain pathogens or of an internal …
Inhibition of heat shock protein family A member 8 attenuates …
2021年8月6日 · Prior studies have placed substantial emphasis on the role of heat shock protein family A member 8 (HSPA8) on postischemic myocardial inflammation and cardiac …
The suppression of HSPA8 attenuates NLRP3 ubiquitination …
2024年5月2日 · Geranylgeranylacetone (GGA)-induced HSPA8 overexpression in cecum ligation and puncture (CLP) mice could significantly reduce systemic inflammatory response and …
Heat shock protein family A member 8 serving as a co-activator of ...
2023年7月20日 · Heat shock protein family A member 8 (HSPA8) participates in the folding or degradation of misfolded proteins under stress and plays critical roles in cancer. In this study, …
HSPA8 acts as an amyloidase to suppress necroptosis by ... - Nature
2023年8月14日 · Here, we identify heat shock protein family A member 8 (HSPA8) as a new type of enzyme — which we name as ‘amyloidase’ — that directly disassembles RHIM-amyloids to …
Effect of HSPA8 gene on the proliferation, apoptosis and immune ...
2023年5月1日 · HSPA8 promotes inflammation by promoting the expression of LPS-induced inflammatory factors. HSPA8 (Heat shock 70 kDa protein 8) is a molecular chaperone involved …
HSPA8 heat shock protein family A (Hsp70) member 8 [ (human)]
HSPA8 Is Identified as a Novel Regulator of Hypertensive Disorders in Pregnancy by Modulating the beta-Arrestin1/A1AR Axis. Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine …
HSPA8 dampens SCAP/INSIG split and SREBP activation by …
A small-molecule inducer of HSPA8 or exosomes containing HSPA8 can restore the regulatory activity of HSPA8, thereby curtailing SREBP signaling, ceasing excessive and unregulated …
HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that
2019年8月7日 · HSPA8 is a crucial molecular regulator of chaperone-mediated autophagy, as a detector of substrates that will be processed by this specialized autophagy pathway. In this …
Human heat shock cognate protein (HSC70/HSPA8) interacts with ...
In the present study, we described the interaction of HSPA8 (HSC70), the constitutive cytosolic member of the HSP70 family, with lipid membranes. HSPA8 showed high selectivity for …