干扰素调节因子3 (Interferon regulatory Factor 3)是干扰素调节因子家族成员之一 ，与病毒感染时干扰素基因的表达密切相关，IRF-3组成性表达在多种细胞中，主要存在于细胞浆中，病毒感染等因素可诱导IRF-3 12C端磷酸化，使IRF-3形成二聚体并移位至细胞核，并与其他转录因子如CBP/p300结合诱导IFNα/β和IFN刺激基因的表达，在抗感染免疫中发挥重要作用。 干扰素调节因子3 (Interferon regulatory Factor 3)是干扰素调节因子家族成员之一 ，与病毒感染时干扰素基 …

IRF3 is a member of the interferon regulatory transcription factor (IRF) family. [5] IRF3 was originally discovered as a homolog of IRF1 and IRF2.

2024年12月25日 · IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and Primary Immunodeficiency With Predisposition To Severe Viral Infection. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Toll Like Receptor 7/8 (TLR7/8) Cascade.

IRF3 (Interferon regulatory factor 3) 作为干扰素调节因子的一员，在抗病毒天然免疫防御方面发挥重要作用。 IRF3 可以调节IFN和IFN诱导基因（ISG）的表达。 干扰素调节因子家族包括 9 个成员。 IRF3 作为细胞抗病毒反应的核心转录因子，在各组织细胞中组成型表达。

The interferon regulatory factor (IRF) family of transcription factors play a vital role in the human innate antiviral immune responses with production of interferons (IFNs) as a hallmark outcome of activation. In recent years, IRF3 has been considered a principal early regulator of type I IFNs (TI- …

2020年10月15日 · Immunity to viruses requires an array of critical cellular proteins that include IFN regulatory factor 3 (IRF3). Consequently, most viruses that infect vertebrates encode proteins that interfere with IRF3 activation. This review describes the cellular pathways linked to IRF3 activation and where tho …

2024年8月9日 · IRF3, a critical component of innate antiviral immune responses, interacts with pro-inflammatory transcription factor NF-κB, and inhibits its activity. This mechanism helps suppress inflammatory gene expression in virus-infected cells and mice.

2024年8月30日 · Here, we show that global IRF3 deficiency delays TLR4-mediated signaling in microglia and attenuates the hallmark features of LPS-induced inflammation such as cytokine release, microglial reactivity, astrocyte activation, myeloid cell infiltration, and …

TANK 可将上游 RLR 信号转导连接至 TANK 结合激酶 1 (TBK1)，TBK1 会诱导干扰素调节因子 3 (IRF-3) 的磷酸化。 IRF-3 磷酸化和随后的二聚化会诱导 IRF-3 核转位，IRF-3 随后结合干扰素刺激应答元件 (ISRE)，从而导致 I 型干扰素基因表达。 胞质双链 DNA 检测也通过多个入口流入 TBK1-IRF-3 信号转导轴。 主要的胞质 DNA 结合感应蛋白是环 GMP-AMP 合成酶 (cGAS)，cGAS 通过产生环二核苷酸 c-GMP-AMP (cGAMP) 对 DNA 结合产生反应。 cGAMP 结合 STING 并激活 …

IFN regulatory factor 3 (IRF3) is a transcription regulator of cellular responses in many cell types that is known to be essential for innate immunity. To confirm IRF3’s broad role in immunity and to more fully discern its role in various cellular subsets, we engineered Irf3 -floxed mice to allow for the cell type-specific ablation of Irf3.