ICOSLG delivers a potent co-stimulatory signal to T cells when engaged by ICOS, resulting in T cell activation and proliferation. The existence of ICOS/ICOSLG signal in vivo is closely associated with many mouse autoimmune disease models. Conversely, the absence of ICOS/ICOSLG signal may be a good way to relieve autoimmune disease.

2025年3月30日 · ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include Immunodeficiency 119 and Dyskeratosis Congenita, Autosomal Dominant 6. Among its related pathways are CD28 Signaling in T-Helper Cell and Immune response NFAT in immune response.

2025年2月8日 · ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells. Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental …

ICOSLG（Inducible T-cell COStimulator Ligand），也称为B7-H2或CD275，是一种免疫检查点分子跨膜蛋白，通常由抗原呈递细胞（如抗原呈递的树突状细胞）和B细胞表达。 其分子结构包括一个Ig-like V型结构域，用于与其受体ICOS结合，以及跨膜区域和细胞内结构域。

Ubiquitous expression in brain (RPKM 4.2), lymph node (RPKM 3.4) and 23 other tissues. 实现相同的蛋白质结合活性。 预计参与 T 细胞受体信号通路和白细胞介素 4 产生的正调控。 位于细胞质核糖核蛋白颗粒和质膜。 [由基因组资源联盟提供，2022 年 4 月] Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production.

ICOSLG is an immune checkpoint expressed by antigen-presenting cells (APC) as well as non-lymphoid cells including mesenchymal stem cells, endothelial cells, fibroblasts, and tumor cells …

2023年10月27日 · ICOS（Inducible T-cell Costimulator）是T细胞上的共刺激分子，与ICOSLG发生配体-受体结合后，可以提供正向信号，促进T细胞的增殖、存活和功能发挥。 ICOS/ICOSLG信号通路在调节T细胞的免疫应答中起着重要作用。 通过ICOS/ICOSLG信号，T细胞可以增强其对抗原的识别和应答能力，促进T细胞的活化和效应功能的发挥。 此外，ICOS/ICOSLG信号通路还参与调节体液免疫和细胞免疫的平衡。 它在刺激B细胞产生抗体、调节T细胞亚群平衡以及免疫耐 …

祁海教授指出，ICOSL（inducible T-cell co-stimulator ligand, also known as ICOSLG，诱导T细胞共刺激配体）不仅促进了TFH细胞发育，还调控了B细胞竞争性参与生发中心反应及形成浆细胞的过程。

2023年9月28日 · In this study, we investigated the expression pattern of ICOSLG in oral squamous cell carcinoma, including tumor cells (TCs), cancer-associated fibroblasts (CAFs) and tumor infiltrating lymphocytes (TILs). Then the clinicopathological features of ICOSLG and its correlation with prognostic value were further analyzed.

2020年3月5日 · Inducible T-cell co-stimulator ligand (ICOSLG) is a member of the B7 family of immune regulatory ligands, expression of which in cancer is implicated in disease progression due to regulation of antitumor adaptive immunity.