Insulin-like growth factor-binding protein - Wikipedia
IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same order of magnitude …
IGFBP7：免疫治疗新靶点 - 知乎 - 知乎专栏
胰岛素样生长因子结合蛋白7 （IGFBP7）是 胰岛素超家族 的生长促进肽成员，可与胰岛素和IGF结合，调控细胞生长和分化。 IGFBP7在不同的肿瘤类型中表现出抑制或促进肿瘤生长的“ …
胰岛素样生长因子结合蛋白IGFBP-3 - 知乎 - 知乎专栏
IGF系统主要由两个IGF（IGF-1 、 IGF-2）、两个IGF受体（IGF-R1 、 IGF-R2）和七个IGF结合蛋白（IGFBPs）组成。 IGFBPs对IGF具有很高的亲和力。 IGFBP-3是出生后血液中含量最丰富 …
IGFBP：病理性疾病和癌症生物标志物 - 知乎 - 知乎专栏
胰岛素样生长因子 1（IGF-1）和IGF-2是胰岛素超家族的生长促进肽成员，与胰岛素共享一个复杂的异构体受体和相关信号分子系统，包括1型IGF受体（IGF1R）、胰岛素受体异构体及其各种 …
胰岛素样生长因子 - 百度百科
胰岛素样生长因子（insulin like growth factor，IGF）是一组具有促生长作用的多肽类物质，其分泌细胞广泛分布在人体肝、肾、肺、心、脑和肠等组织中。 IGF族有IGF-Ⅰ和IGF-Ⅱ两种。 IGF …
Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3 ... - PubMed
2020年5月5日 · Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an …
The insulin-like growth factor-binding protein (IGFBP) superfamily
Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of other …
Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
2018年8月29日 · Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, …
IGF-Binding Proteins: Why Do They Exist and Why Are There So …
2018年4月8日 · Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in …
Signaling Pathways of the Insulin-like Growth Factor Binding …
Insulin-like growth factor binding proteins (IGFBPs) are a family of 6 homologous proteins that bind IGF-1 and IGF-2 with high affinity. IGF-1 and IGF-2 signaling through their principal …