IKK是一种常见的 转录因子 激活蛋白 [1]，可以被位于 细胞质膜 的 TNF -TNFR复合体、 IL -ILR复合体、活化的 Toll样受体 、 病毒感染 和胞外电离辐射激活。 常见的 炎症因子 (包括IL-α …

In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are …

IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine -activated intracellular signaling pathway involved in triggering immune responses. …

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the …

The IKK kinase complex is the core element of the NF-κB cascade. It is essentially made of two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. Additional components may …

2006年10月17日 · IKKbeta (and IKKgamma) are essential for rapid NF-kappaB activation by proinflammatory signaling cascades, such as those triggered by tumor necrosis factor alpha …

IκB 激酶（IκB kinase;IKK）是一个生物化学与分子生物学名词。 一种丝氨酸特异的蛋白激酶，由多组分构成。 可被细胞外刺激激活、催化IκB (NF-κB的抑制蛋白)特异位点的磷酸化，导致IκB …

The inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex is the master regulator of the NF-κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly stimulus …

2018年1月1日 · IKK (IκB kinase) is the central regulator of the NF-κB signaling pathway, which plays a key role in immunity, inflammation, and cell survival (Karin and Ben-Neriah 2000; …

Present at the end of both pathways are the proteins NF-κB, IκB, and the IκB kinase (IKK). These proteins work together to deliver the myriad outcomes that influence context-dependent …