2017年9月12日 · IL-36（白细胞介素-36）是新的促炎细胞因子。 可由单核细胞、T 淋巴细胞、角质细胞等多种细胞产生。 结构：由 3 个生物学功能相似的分子 IL-36α、IL-36β、IL-36γ组成，归属 Th2 型细胞因子。 人类 IL-36 基因存在于 2 号染色体上，由 12 条β管状线组成，含有β-三叶草二级结构，其结构模型和经典的 IL-1 家族相似。 功能：IL-36α，IL-36β和 IL-36γ通过 IL-1Rrp2 和 IL-1RAcP 激活 NF-κB 和丝裂原激活蛋白激酶 (MAPK) 途径产生大量的细胞因子、趋化因子、黏附 …

IL-36通过IL-36R和IL-1受体辅助蛋白（IL-1 receptor accessory protein, IL-1RAcP）介导细胞内信号转导。 在人体内，编码IL-36Ra的基因失活突变会导致IL-36R信号失调，主要表现为弥漫型脓疱银屑病，这表明IL-36在银屑病的皮肤炎症中有重要作用。

Interleukin 36, or IL-36, is a group of cytokines in the IL-1 family with pro-inflammatory effects. The role of IL-36 in inflammatory diseases is under investigation. [1] There are four members of the IL-36 family which bind to the IL-36 receptor (IL1RL2/IL-1Rrp2/IL-36 receptor dimer) with varying affinities. [2]

公开资料显示，BI655130是一款“first-in-class”在研新药，可阻断白细胞介素-36受体（IL-36R）的作用，具有治疗皮肤病、 掌跖脓疱病 、溃疡性结肠炎等多种炎症性疾病的潜力，全球范围内已进入3期临床试验阶段。

Protease mediated N-terminal processing is needed for cytokine activation. In the skin, the functional role of IL-36 is to contribute to host defense through inflammatory response. However, when dysregulated, IL-36 stimulates keratinocyte and immune cells to enhance the Th17/Th23 axis and induces psoriatic-like skin disorder.

The IL-36 subfamily of cytokines belongs to the IL-1 superfamily and consists of three pro-inflammatory agonists IL-36α, IL-36β, IL-36γ, and an IL-36 receptor (IL-36R) antagonist, IL-36Ra. These IL-36 cytokines function through a common receptor to modulate innate and adaptive immune responses.

2022年4月26日 · Increasing evidence in the IL-36 pathway demonstrates their potential as a therapeutic target for treating inflammatory skin diseases, such as generalized pustular psoriasis (GPP).

Interleukin (IL)-36 signal pathways induce inflammatory responses. Pro-IL-36 cytokines are inactive proteins and require post-translational processing to fully unleash the pro-inflammatory activity. IL-36 agonists bind to heterodimeric receptor complexes, including IL-36 receptor (IL-36R) and co-receptor IL-1 receptor accessory protein (IL-1RAcP).

2021年2月4日 · 最近的一项研究使用il-36基因治疗实验性纤维肉瘤，il-36治疗导致显著减少肿瘤生长，表明有抗肿瘤作用。 结肠癌中，高表达IL-36α和IL-36β或IL-36α加上低水平的IL-36γ，表现出更长生存时间。

2013年12月15日 · In this review the discovery and biological function of the cytokines IL-36α, IL-36β, IL-36γ and IL-36Ra will be discussed, and their role in the pathogenesis of a wide variety of diseases. Keywords: IL-1 family; Interleukin-36; Pathogenesis; Skin inflammation.