Interleukin 16 (IL-16) is released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4.

2017年9月1日 · 白细胞介素-16 是一种具有多种生物学活性的细胞因子, 由 CD8+T 淋巴细胞分泌。 IL-16 最初在外周血单核细胞 (peripheral blood mononuclearcells,PBMCs) 内发现, 对人 T 细胞具有趋化作用，参与炎症反应，在多种肿瘤中表达明显增高，在肿瘤的发生发展中发挥着至关重要的作用。 三、一般性质. 白细胞介素 16 (IL-16) 能诱导人 CD4+淋巴细胞、单核细胞和嗜酸性细胞迁移; 诱导人 CD4+淋巴细胞和单核细胞的 IL-2R 和 HLA-DR 表达; 通过 CD4+受体与 T 细胞结合; …

Interleukin 16 (IL-16), formerly known as lymphocyte chemoattractant factor or LCF, is a pro-inflammatory cytokine that is chemotactic for CD4 + T lymphocytes, monocytes, and eosinophils.

2024年12月25日 · IL16 (Interleukin 16) is a Protein Coding gene. Diseases associated with IL16 include Whipple Disease and Graves Disease . Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway .

Interleukin-16 (IL-16) is generated as a precursor molecule that is cleaved by caspase-3 to produce a pro-IL-16 molecule that functions as a regulator of T cell growth, and a secreted peptide that functions as a CD4 and/or CD9 ligand for induction of cell motility and activation. IL-16 has been pred …

Interleukin 16 (IL-16) was initially described in 1982 as the first T cell chemoattractant. Through interaction with CD4, IL-16 has now been characterized as a chemoattractant for a variety of CD4+ immune cells.

2025年3月10日 · In terms of the prognostic potential of IL-16, we found that low IL16 expression was significantly correlated with inferior survival of patients in 10 out of 31 TCGA cancer types (32.2% ...

白细胞介素-16是医学术语。 主要由活化的CD8+T细胞产生，受体是CD4，能趋化CD4+T细胞、单核细胞和嗜酸性粒细胞，诱导T细胞和单核细胞表达IL-2R和HLAII类分子。 白细胞介素-16是医学术语。

IL-16 selectively regulates migration of all CD4 expressing T cells regardless of their activation state, which is of critical importance for immune modulation and potential therapy of MS.

The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins.