Interleukin 6 - Wikipedia
In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also …
IL-6 in Inflammation, Immunity, and Disease - PMC
HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein β (NF-IL6) transcription factors. J Biol …
IL6 Gene - GeneCards | IL6 Protein | IL6 Antibody
2024年12月25日 · IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is …
Interleukin-6: A Masterplayer in the Cytokine Network - PubMed
Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the …
What is Interleukin 6? - News-Medical.net
2021年3月29日 · Image Credit: StudioMoleKuul / Shutterstock.com IL-6 and inflammation. Besides being an immune protein, IL-6 is also a pyrogen and is responsible for fever in …
IL-6: A cytokine at the crossroads of autoimmunity - PMC
IL-6 is implicated in the development and progression of autoimmune diseases in part by influencing CD4 T cell lineage and regulation. Elevated IL-6 levels drive inflammation in a wide …
Interleukin-6 signalling in health and disease - PMC
Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 …
Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in ...
2021年5月17日 · Thériault S, Dina C, Messika-Zeitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, et al; D.E.S.I.R. Study Group. …
IL-6 as a keystone cytokine in health and disease - Nature
2015年4月21日 · Almost all stromal cells and cells of the immune system produce IL-6, and while IL-1β and tumor-necrosis factor are major activators of IL6 expression, other pathways such …
IL-6 in inflammation, immunity, and disease - PubMed
2014年9月4日 · Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase …