2024年4月18日 · Check the status of your federal income tax refund using IRS2Go. You can check your refund status within 24 hours after we receive your e-filed return, or about four (4) weeks after mailing your paper return.

2024年12月25日 · IRS2 (Insulin Receptor Substrate 2) is a Protein Coding gene. Diseases associated with IRS2 include Type 2 Diabetes Mellitus and Polycystic Ovary Syndrome. Among its related pathways are IL-9 Signaling Pathways and Insulin receptor signalling cascade.

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors.

In type 2-diabetes and impaired glucose tolerance, the muscle, fat and liver become resistant to insulin, and recent developments place dysregulation of insulin receptor substrate (IRS) expression and activation at the center of such defects.

Insulin receptor substrate 2 (IRS2) is a widely expressed protein that regulates crucial biological processes including glucose metabolism, protein synthesis, and cell survival. IRS2 is part of the insulin - insulin-like growth factor (IGF) signaling pathway …

2016年10月6日 · We demonstrate that hepatic Irs2-knockout mice develop ‘selective insulin resistance’, whereas mice lacking in Irs1, or both Irs1 and Irs2, develop ‘total insulin resistance’.

2025年3月4日 · Title: Enhancer RNA IRS2e is essential for IRS2 expression and the oncogenic properties in oral squamous cell carcinoma. Identification of the ageing-related prognostic gene signature, and the associated regulation axis in skin cutaneous melanoma.

1995年9月14日 · Alignment of the sequences of IRS-2 and IRS-1 revealed a highly conserved amino terminus containing a pleckstrin-homology domain and a phos-photyrosine-binding domain, and a poorly conserved...

Insulin receptor substrate 2 (IRS2) is an essential adaptor that mediates signaling downstream of the insulin receptor and other receptor tyrosine kinases. Transduction through IRS2-dependent pathways is important for coordinating metabolic homeostasis, and dysregulation of IRS2 causes systemic insu …

2024年12月9日 · This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors.