2024年12月25日 · KLF5 (KLF Transcription Factor 5) is a Protein Coding gene. Diseases associated with KLF5 include Cardiomyopathy, Dilated, 1Ff and Cardiomyopathy, Familial Hypertrophic, 25. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and White fat cell differentiation.

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene. [5][6] This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor. [6]

Krüppel-like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration.

KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a number of gene promoters and regulating their transcription. KLF5 is expressed during development and, in adults, with higher levels in proliferating epithelial ...

2024年4月22日 · KLF5 regulates actin remodeling and lamellipodia formation to promote the metastasis of NPC cells in vitro and in vivo. Mechanistically, KLF5 preferentially occupies distal enhancer regions of...

2023年9月14日 · 基于RNA-seq、ChIP-seq技术发现KLF5通过结合在RAD51启动子区域重塑RAD51的转录，进一步影响卵巢癌的同源重组信号通路。 进一步，作者使用IP-mass实验发现KLF5与EHF和ELF3形成转录复合物，调控RAD51的转录过程。

2024年11月27日 · KLF5 strengthens drug resistance of ovarian cancer stem-like cells by regulating survivin expression. Dong Z, et al. Cell Prolif, 2013 Aug. PMID 23869764, Free PMC Article. Restoring KLF5 in esophageal squamous cell cancer cells activates the JNK pathway leading to apoptosis and reduced cell survival. Tarapore RS, et al. Neoplasia, 2013 May.

2023年9月13日 · 为了更好地了解klf5对rad51的特异性转录调控机制，他们首先使用klf5靶向抗体进行蛋白质免疫沉淀，然后进行质谱 (ip-mass)分析，发现了48个潜在的与klf5相互作用的蛋白质，其中包括9个核蛋白（图 6a ）。

2024年9月20日 · klf5通过与dna的g/c富集序列结合，调控一系列与细胞增殖、代谢和生存相关的 基因表达。 它既能作为转录激活因子，也能作为抑制因子，取决于它与哪些辅助因

该基因编码锌指蛋白 Kruppel 样因子亚家族的成员。 编码的蛋白质是一种转录激活剂，可直接结合目标基因启动子中的特定识别基序。 该蛋白作用于多种不同信号通路的下游，并受翻译后修饰的调控。 它可能参与促进和抑制细胞增殖。 该基因的表达可能在多种不同的癌症和心血管疾病中发生改变。 可变剪接导致多个转录本变体。 [RefSeq 提供，2013 年 11 月] This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins.