There is growing evidence for a causal role of the KDM5 family of histone demethylases in human cancer. In particular, KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) contribute to …

Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene. [5][6] The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds …

KDM5）是JMJD（jumonji domain containing）家族 中重要的一员，通过特异性去除组蛋白 3第4位赖 氨酸（H3K4）甲基化修饰，参与表观遗传调控过 程，与肿瘤、免疫、耐药等疾病的发 …

kdm5b是一种组蛋白去甲基化酶，是kdm5 4种亚型中的一种，参与表观遗传调控过程，与肿瘤等疾病有密切关系。上述结果表明kdm5b可能是icb响应低的生物标志物，靶向kdm5b可能诱导t细 …

2021年8月5日 · KDM5 inhibition reverts the effects of KMT2D mutations by increasing levels of H3K4me3 and restoring expression of KMT2D-regulated genes. Loss-of-function mutations in …

2022年12月12日 · In this review, we adopt a unique perspective regarding the context-dependent roles of KDM5A and KDM5B in development and tumorigenesis. It is well known that these …

kdm5抑制剂对干扰素信号通路的激活作用，可以显著提高细胞对病毒感染的抵抗力。 随后，研究人员用 CRISPR/Cas9技术 ，逐个敲除涉及干扰素信号通路激活的基因，并检测其对KDM5抑 …

2021年10月20日 · Here we show that, in mouse melanoma models, depletion of KDM5B—an H3K4 demethylase that is critical for melanoma maintenance and drug resistance 13, 14, 15 …

Here, we provide an overview of the roles of KDM5 in cancer, explore the molecular mechanisms through which KDM5 regulates transcriptional output, including our recent finding that KDM5A …

2024年5月20日 · Several KDM5 inhibitors have shown potent BC inhibitory activity in vitro and in vivo, but challenges still exist in developing KDM5 inhibitors. In this review, we introduce the …