2024年12月25日 · LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4) is a Protein Coding gene. Diseases associated with LGR4 include Delayed Puberty, Self-Limited and Bone Mineral Density Quantitative Trait Locus 17. Among its related pathways are Signaling by WNT and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

2016年4月11日 · LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting promotes reduced bone loss...

2024年1月31日 · 研究团队开发了靶向LGR4的单克隆抗体——LGR4-mAb，其可有效抑制LGR4-Wnt信号转导，与化疗药物联用时可显著增强化疗耐药的肿瘤类器官的铁死亡，从而为对抗难治性和复发性癌症开辟了新思路。

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene. [5] [6] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone. Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4/GPR48), a member of the GPCR (G protein-coupled receptors) superfamily, subfamily B, is a common intestinal crypt stem cell marker. It binds R-spondins/Norrin as classical ligands and plays a crucial role in Wnt signaling potentiation.

本文将详细介绍LGR4基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面理解这一重要的G蛋白偶联受体。 LGR4，全名 leucine rich repeat containing G protein-coupled receptor 4，位于染色体11p14.1，是一个具有蛋白质产物的基因。 它属于G蛋白偶联受体（GPCR）家族中的A类孤儿受体（orphan receptors），这意味着它目前还没有明确的内源性配体。 LGR4在多种生物学过程中发挥关键作用，特别是在组织再生和癌症发展中。 组织再生：在肠道、皮肤等组 …

2024年5月23日 · Here, we report that deficiency of Lgr4 (Lgr4iKO) in intestinal epithelium decreased the proportion of enterocytes selective for long-chain fatty acid absorption, leading to reduction in lipid...

2020年7月28日 · 该研究首次发现富含亮氨酸重复序列的G蛋白偶联受体（leucine-rich repeat-containing G protein-coupled receptor，LGR）家族成员Lgr4调控巨噬细胞促炎激活参与心肌梗死后损伤修复的关键作用和机制。 Lgr4作为膜受体，介导胞膜内外信号转导，除了激活经典的cAMP/PKA/CREB（cAMP responsive element binding protein）信号通路，还可与内源性配体R-spondins（RSPOs）家族蛋白结合，增强Wnt信号通路的激活。 Lgr4基因调控细胞的增殖和 …

2023年7月11日 · LGR4 is a new member of this G protein-coupled receptor family and shows ways of expression and function similar to those of LGR1/2/3. Several recent studies have reported that, unlike LGR5/6, LGR4 plays essential roles in endocrine and metabolic diseases, including hypothalamic-gonadal axis defects, mammary gland dysplasia, osteoporosis ...

2022年5月30日 · Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4/GPR48), a member of the GPCR (G protein-coupled receptors) superfamily, subfamily B, is a common intestinal crypt stem cell marker. It binds R-spondins/Norrin as classical ligands and plays a crucial role in Wnt signaling potentiation …