Leucine-rich alpha-2-glycoprotein 1 is a protein which in humans is encoded by the gene LRG1. [5] The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation. [5][6]

2024年12月25日 · LRG1 (Leucine Rich Alpha-2-Glycoprotein 1) is a Protein Coding gene. Diseases associated with LRG1 include Appendicitis and Cecal Disease. Among its related pathways is Innate Immune System. Gene Ontology (GO) annotations related to this gene include transforming growth factor beta receptor binding. An important paralog of this gene is CHADL.

2022年1月21日 · 大约十年前，分泌性富含亮氨酸的 α-2 糖蛋白 1 (LRG1) 首次被描述为致病性眼部新生血管形成的关键参与者。 从那时起，越来越多的出版物报道了 LRG1 与多种人类疾病有关，包括癌症、糖尿病、心血管疾病、神经系统疾病和炎症性疾病。 本综述的目的是首次对 LRG1 文献进行全面概述，考虑其在健康和疾病中的作用。 尽管LRG1由肝细胞和中性粒细胞组成型表达，但Lrg1−/−小鼠没有表现出明显的表型异常，这表明LRG1在发育和体内平衡中本质上是多余 …

2025年2月25日 · Leucine-rich alpha-2-glycoprotein 1 (LRG1), a secretory glycoprotein associated with angiogenesis, inflammation, fibrosis, and other pivotal pathophysiological processes, is significantly upregulated in corneal neovascularization (CNV), where it drives neovascularization via the TGF-β-Smad signaling …

2022年1月21日 · Leucine-rich α-2 glycoprotein 1 (LRG1) is a secreted member of the family of leucine-rich repeat (LRR) proteins and was first discovered in human serum in 1977 [1]. The LRR motifs are evolutionarily conserved and have been found in plants, animals, bacteria, and fungi.

2013年7月17日 · LRG1 is identified as a new regulator of TGF-β signalling that promotes angiogenesis via a TβRII–ALK1–ENG–Smad1/5/8 signalling pathway; antibody-mediated inhibition of LRG1 reduces ...

2022年1月21日 · The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since then, an increasing number of publications have reported the involvement of LRG1 in multiple human conditions including cancer, diab …

2023年5月1日 · Here, we determined the crystal structure of LRG1, identifying the horseshoe-like solenoid structure of LRG1 and its four N-glycosylation sites.

2025年2月8日 · LRG1 plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC) by regulating RUNX1 expression. LRG1 may be a potential detection biomarker as well as a marker for monitoring recurrence and therapeutic target for CRC. These findings suggest that sputum LRG is a promising biomarker of local inflammation in asthma.

LRG1 is a novel HER3 ligand and mediates liver-mCRC crosstalk. The LRG1-HER3 signaling axis is distinct from canonical HER3 signaling and represents a new therapeutic opportunity to treat patients with mCRC, and potentially other types of liver metastases.