Initially, two lipoxins were identified, lipoxin A 4 (LXA 4) and LXB 4, but more recent studies have identified epimers of these two LXs: the epi-lipoxins, 15-epi-LXA 4 and 15-epi-LXB 4 …

2024年4月26日 · LXA4 treatment protects against oxidative stress-induced H 2 O 2 damage by reducing ROS, lactate dehydrogenase (LDH), and malondialdehyde (MDA) leakage, while …

Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and …

2024年11月21日 · The preclinical study, published in Cardiovascular Diabetology, found LXA4, which is known for its "calming agent" action in turning off the body's inflammatory response …

2018年5月1日 · Lipoxin A4 (LXA4) is an immunoresolvin family member derived from arachadonic acid that signals primarily through the formyl peptide receptor 2 (FPR2). Limited reports …

2022年11月4日 · Lipoxin A4 (LXA4) is a specialized pro-resolving mediator involved in the resolution phase of inflammation that is crucial for the return of tissues to homeostasis, …

Lipoxin A4: Produced by the metabolism of 15-HETE or 15-HpETE with leukocytes. CAS Number: 89663-86-5. Synonyms: LXA4, 5(S),6(R),15(S)-TriHETE. Purity: ≥95%.

15(R)-Lipoxin A4: An aspirin-triggered lipoxin. CAS Number: 171030-11-8. Synonyms: AT-Lipoxin A4, 15-epi Lipoxin A4, 15(R)-LXA4. Purity: ≥95%.

15 (R)-Lipoxin A4 (15-epi-LXA4) is a STAT-6 activator and a lipid-derived lipoxin-type specialized pro-resolving mediator (SPM) that plays a role in promoting inflammation resolution and …

Acetylation of cyclooxygenase-2 (COX-2) by aspirin can trigger 15-epi-LXA4 (ATL) biosynthesis. Elucidating the pharmacological actions of lipoxins and ATL was facilitated by total synthesis …