基于配体的药物设计(Ligand‐based drug design, LBDD)
基于配体的药物设计（LBDD）：在生物靶点结构未知的情况下，通过研究与靶点具有特异性结合配体的结构信息，发现先导化合物的方法。 量衣裁衣。 基于配体的药物设计（LBDD）： 分 …
Ligand-based drug design (LBDD) - ScienceDirect
2022年1月1日 · The ligand-based drug design (LBDD) and structure-based drug design (SBDD) are the techniques used for the hit identification in the drug design process. In the ligand …
计算机辅助药物设计（三） - 知乎专栏
基于配体的药物设计 （LBDD） 基本原理. 基于配体的药物设计（Ligand-based Drug Design，LBDD）是药物研发中的一种方法，主要依赖于已知的配体（通常是具有活性的小分 …
JDDT深度报道药物研发的三种方法：虚拟筛选、分子对接和QSAR
基于结构的药物设计 （SBDD）和 基于配体的药物设计 （LBDD）是 计算机辅助药物设计 （CADD）在现代药物发现和开发中应用的两种基本方法。 虚拟筛选 作为高通量筛 …
Molecular Docking and Structure-Based Drug Design Strategies
Ligand-based virtual screening (LBVS), similarity searching, QSAR modeling and pharmacophore generation are some of the most useful LBDD methods [8]. SBDD and LBDD approaches …
Computer-Aided Drug Design Methods - PubMed
Structure-based drug design (SBDD) and ligand-based drug design (LBDD) are the two general types of computer-aided drug design (CADD) approaches in existence.
Chapter 2 - Structure- and ligand-based drug design - ScienceDirect
2021年1月1日 · Computer-aided drug design (CADD) saves up to 30% of the time and money of a drug development process and has become an integral part of research and development in …
Ligand-based drug design – REVIVE
Ligand-based drug design (LBDD) is a drug discovery approach based on knowledge of molecules with biological activity. It is an approach that is independent of any information …
Ligand-based drug designing - ScienceDirect
2022年1月1日 · In the SBDD, three-dimensional (3D) structures are prepared by using three different approaches: (1) sketching macromolecular structures in the fragment libraries using …
(PDF) Structure- and ligand-based drug design: concepts, approaches ...
2021年1月1日 · It takes more than 10 years to bring a drug to the market and costs an average cost of US $2.6 billion. Computer-aided drug design (CADD) saves up to 30% of the time and …