The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) [5] that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL).

ldlr，低密度脂蛋白受体相关蛋白是近年来发现的一种细胞表面蛋白,属于一种内吞性受体,系低密度脂蛋白受体基因家族中的一员.由于其能够与多种结构及功能各异的配体相互作用,不仅可以对血脂的动态平衡及纤溶功能的稳定进行调节,而且能参与多种生长因子 ...

Low density lipoprotein receptor (LDLR) is responsible for uptake of cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at the cell surface and releases them in the low-pH environment of the endosome. 低密度脂蛋白受体 (LDLR) 负责将携带胆固醇的脂蛋白颗粒吸收到细胞中。

2024年12月25日 · LDLR (Low Density Lipoprotein Receptor) is a Protein Coding gene. Diseases associated with LDLR include Hypercholesterolemia, Familial, 1 and Homozygous Familial Hypercholesterolemia. Among its related pathways are Familial hyperlipidemia type 1 and Statin inhibition of cholesterol production.

2021年10月18日 · 低密度脂蛋白受体 （Low-Density Lipoprotein (LDL) Receptor），又称 LDL受体，为一种膜镶嵌式蛋白质，全长有839个 氨基酸 （扣掉21氨基酸长的 讯息肽） [1]。 本受体调控 低密度脂蛋白 （LDL）的 胞吞作用。 此种受体专门辨认LDL颗粒上的B100 脂蛋白，也可辨认 乳糜微粒 残体及 中间密度脂蛋白 （IDL， 极低密度脂蛋白 的残体）上的Apo E。 人体LDL受体的基因编码为 LDLR 基因 [2][3]。 属于 低密度脂蛋白受体家族 （英语：Low density lipoprotein …

LDLR is a cell membrane glycoprotein that functions in the binding and internalizing of circulating cholesterol-containing lipoprotein particles. LDLR is ubiquitously expressed and is a key receptor for maintaining cholesterol homeostasis in mammals. LDLR-mediated endocytosis is essential for lipoprotein and lipid metabolism .

The role of these receptor proteins in pathogenesis of diverse metabolic risk factors is emerging, rendering them targets of novel therapeutics for metabolic syndrome and atherosclerosis. This manuscript reviews the physiological role of the LDLR family of proteins and describes its involvement in pathogenesis of hyperlipidemia and atherosclerosis.

The LDLR gene provides instructions for making a protein called the low-density lipoprotein receptor. This receptor binds to particles called low-density lipoproteins (LDLs), which are the primary carriers of cholesterol in the blood.

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell.

2025年3月2日 · Low density lipoprotein receptor (LDLR) is involved in cholesterol metabolism and plays an important role in maintaining the cholesterol homeostasis of organism cells. The expression of LDLR is precisely regulated by transcription, post-transcription and post-translation, and the imbalance of ldlr expression will lead to the occurrence and ...