2024年12月25日 · LHX6 (LIM Homeobox 6) is a Protein Coding gene. Diseases associated with LHX6 include Geotrichosis and Stuttering. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is LHX8.

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation …

2017年8月23日 · Here we show that a subset of GABAergic neurons in the mouse ventral zona incerta, which express the LIM homeodomain factor Lhx6 and are activated by sleep pressure, both directly inhibit...

LHX6是一种由lhx6基因编码的人类蛋白。 该基因编码大蛋白家族中的一种蛋白，这种蛋白含LIM域和其特有的富半胱氨酸锌结合域。 研究显示精神分裂患者认知障碍与该蛋白质有关 。

In this review, we first summarize Lhx6 and -8 distributions in development and then explore how Lhx6 and -8 act as transcription factors and coregulators of cell lineage specification. Known Lhx6 and -8 functions and targets are outlined in neurogenesis, craniofacial development, and germ cell …

Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

Based on hPSC neural differentiation, we describe the role of LHX6 in human GABA interneuron migration by using knockout/overexpression strategies. In this study, we found that LHX6 is critical for controlling human GABAergic interneuron migration, which is confirmed with previous studies from lhx6 transgenic rodents (Liodis et al., 2007). The ...

LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons Protein Cell . 2020 Apr;11(4):286-291. doi: 10.1007/s13238-019-00686-6.

2025年1月4日 · LHX6 is a putative tumour suppressor gene with epigenetic silencing in lung cancer. LHX6 is a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis; found positive association of LHX6 with Tourette syndrome in some European populations, not others.

2017年9月5日 · 为了验证表达Lhx6的神经元在调节睡眠过程中所扮演的角色，研究人利用DREADDs技术（designer receptors exclusively activated by designer drugs），构建了被设计药物特异性激活的设计受体，以增加小鼠神经元的活动，并观察它们的行为。