An R-loop is a three-stranded nucleic acid structure, composed of a DNA: RNA hybrid and the associated non-template single-stranded DNA. R-loops may be formed in a variety of circumstances and may be tolerated or cleared by cellular components.

An R-loop is a three-stranded nucleic acid structure that consists of a DNA:RNA hybrid and a displaced strand of DNA. R-loops occur frequently in genomes and have significant physiological importance. They play vital roles in regulating gene ...

R loops are non-B DNA structures that form during transcription when the nascent RNA anneals with the template DNA strand, thus displacing the non-template DNA strand.

2019年2月7日 · R-loops are nucleic acid structures that form when an RNA strand invades double-stranded DNA. This produces a Watson-Crick RNA-DNA hybrid and displaces the non-hybridized strand as single-stranded DNA (ssDNA). The term R-loop is analogous to a D-loop containing an RNA moiety (Thomas et al., 1976).

2024年6月24日 · R-loops are three-stranded nucleic acid structures that are abundant and widespread across the genome and that have important physiological roles in many nuclear processes. Their accumulation...

2022年9月20日 · R-loops are structures containing an RNA-DNA duplex and an unpaired DNA strand. They can be formed upon “invasion” of an RNA strand into a DNA duplex, during which the RNA displaces the homologous DNA strand and binds the complementary strand.

2020年5月1日 · R-loop biology is emerging as a model to study genomic instability and disease. In broader terms, at molecular level R-loop biology connects the 3Rs of biology i.e. replication, repair and recombination along with transcription and splicing.

2020年1月24日 · An R-loop is a three-stranded nucleic acid structure that consists of a DNA:RNA hybrid and a displaced strand of DNA. R-loops occur frequently in genomes and have significant physiological importance. They play vital roles in regulating gene expression, DNA replication, and DNA and histone modificat …

These unusual nucleic acid structures are called R-loops. Studies in the last decades concentrated on the detrimental effects of R-loop formation, particularly on genome stability. In fact, R-loops are thought to play a role in several human diseases like cancer and neurodegenerative syndromes.

15 小时之前 · For example, aPKC phosphorylates multiple sites within an unstructured loop between blades 10 and 11 of the double β-propeller structure of the lateral polarity protein lethal giant larvae (LGL).