A549 cell - Wikipedia
A549 cells are adenocarcinomic human alveolar basal epithelial cells, and constitute a cell line that was first developed in 1972 by D. J. Giard, et al. through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58-year-old caucasian male. [1]
A549 - CCL-185 - ATCC
A549 cells were isolated from the lung tissue of a White, 58-year-old male with lung cancer. This cell line can be used in cancer, immuno-oncology, and toxicology research.
Non-small-cell lung cancer cell lines A549 and NCI-H460 express ...
The human non-small-cell lung cancer cell lines H460 and A549 were obtained from the American Type Culture Collection (Rockville, MD, USA). H460 cells were grown in RPMI 1640 medium supplemented with 10% fetal bovine serum and 2 mM L-glutamine (all …
Everything You Need To Know About A549 Cells - Synthego
The A549 cell lines are the most commonly used human non-small cell lung cancer cell lines for both basic research and drug discovery. In this article, we will cover every topic about this cell line, ranging from general information to research applications.
A549 Cell Line: A Keystone in Lung Cancer Research - Cytion
The A549 cell line is widely used in cancer research because it provides a consistent, reproducible model for studying the molecular biology of lung cancer, testing chemotherapeutic agents, understanding drug resistance mechanisms, and exploring gene expression related to lung adenocarcinoma.
A549 – A model for non-small cell lung cancer - Labcorp
2016年5月1日 · Today a large number of human non-small cell lung cancer cell lines exist that are being used for both basic research and drug discovery. One commonly used line is A549, an epithelial carcinoma derived from a 58 year old male patient, known to be KRAS mutant and EGFR wild type.
Long Term Culture of the A549 Cancer Cell Line Promotes …
One such commonly used cell model is the lung carcinoma cell line A549. Isolated in 1973 from a pulmonary adenocarcinoma [26] and subsequently characterized as being representative of ATII cells [3, 27 – 29], this cell line has been a mainstay of …
Long Term Culture of the A549 Cancer Cell Line Promotes ... - PLOS
2016年10月28日 · Lung surfactant has a role in immune protectiveness and the production of complement and our finding of up-regulated gene expression of C3, C4b and C5 suggest the synthesis of components of the classical and alternate complement pathways by the long term A549 cell cultures consistent with their differentiation into a more ATII-like phenotype.
Cisplatin-resistant A549 non-small cell lung cancer cells can be ...
2019年11月29日 · In this study, we take advantage of the paraclonal A549 subpopulation as a highly defined model to study how mitochondrial activity is associated with resistance to MTA and cisplatin, the components of the lung adenocarcinoma gold standard combination therapy. We found that cisplatin targets cells with a high mitochondrial activity.
Cisplatin-resistant A549 non-small cell lung cancer cells can be ...
2019年11月29日 · This study revealed that cisplatin resistant A549 lung cancer cells can be identified by their increased levels of mitochondrial mass. However, Mito-High cells feature an increased sensitivity to pemetrexed treatment. Thus, pemetrexed and cisplatin target reciprocal lung cancer subpopulations, which …