LYL1 Gene - GeneCards | LYL1 Protein | LYL1 Antibody
2024年12月25日 · LYL1 (LYL1 Basic Helix-Loop-Helix Family Member) is a Protein Coding gene. Diseases associated with LYL1 include Leukemia, Acute Lymphoblastic and Leukemia. Among its related pathways are Signaling by NTRKs and Nuclear Events (kinase and …
LYL1 - Wikipedia
17095 Ensembl ENSG00000104903 ENSMUSG00000034041 UniProt P12980 P27792 RefSeq (mRNA) NM_005583 NM_008535 RefSeq (protein) NP_005574 NP_032561 Location (UCSC) Chr 19: 13.1 – 13.1 Mb Chr 8: 85.43 – 85.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene. Interactions LYL1 has been shown to interact with TCF3 and ...
LYL1 facilitates AETFC assembly and gene activation by ... - PNAS
LYL1 is a transcription factor that contains a basic helix–loop–helix (bHLH) domain and is important for hematopoietic stem/progenitor cells (6, 18). Structurally, both LYL1 and its homolog TAL1 form DNA binding heterodimers with E proteins, such as E2A and HEB, which are also bHLH factors . LYL1 and TAL1 also directly interact with nuclear ...
LYL1 LYL1 basic helix-loop-helix family member [ (human)]
LYL1 facilitates AETFC assembly and gene activation by recruiting CARM1 in t(8;21) AML. Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia. Repression of LYL1 contributes to t(8;21) leukemic cell differentiation.
Oncogenic potential of the transcription factor LYL1 in acute ...
2005年8月11日 · The LYL1 gene encodes a basic helix–loop–helix transcription factor involved in T-cell acute lymphoblastic leukemia.
清华大学陈默课题组合作揭示白血病关键转录复合物的组成机制和 …
2022年10月12日 · lyl1是含有碱性螺旋环螺旋（bhlh）结构域的转录因子，能够与e蛋白如e2a和heb形成异源二聚体结合于dna，对造血干细胞/祖细胞很重要。lyl1还可以直接与辅助因子lmo2蛋白相互作用，形成转录复合物，驱动造血细胞和恶性肿瘤中的谱系特异性基因表达。
LYL1 基本螺旋-环-螺旋家族成员（LYL1）基因 | MCE
LYL1 基本螺旋-环-螺旋家族成员： 该基因代表基本的螺旋-环-螺旋转录因子。编码的蛋白质可能在血管成熟和造血中发挥作用。该基因座与 7 号染色体上的 T 细胞受体 β 基因座 (GeneID 6957) 之间的易位与急性淋巴细胞白血病有关。[RefSeq 提供，2010 年 9 月]
LYL1 LYL1 basic helix-loop-helix family member [Homo sapiens …
2024年8月17日 · Title: Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia. Repression of LYL1 contributes to t(8;21) leukemic cell differentiation.
A novel role for Lyl1 in primitive erythropoiesis - PubMed
2018年10月11日 · Stem cell leukemia ( Scl or Tal1 ) and lymphoblastic leukemia 1 ( Lyl1 ) encode highly related members of the basic helix-loop-helix family of transcription factors that are co-expressed in the erythroid lineage. Previous studies have suggested that Scl is essential for primi …
Lyl1大鼠基因|Lyl1基因信息|Lyl1蛋白相互作用-RDDC官网
预测能够使dna结合的转录因子活性增强，特异性结合rna聚合酶ii和rna聚合酶ii的顺式调控区域序列。参与血管成熟、造血和转录调控。定位在细胞核中。该基因的人类同源物与t细胞急性淋巴细胞白血病有关。与人类lyl1(lyl1基本螺旋-环-螺旋家族成员)同源。